Table 5.

Efficacy of hyperthermia in case reports

Reference	Intervention, Duration of target temp. per session, Period of time of the study	Number of participants, Cancer Type	Outcome
Outcome: Tumour response
Bakhshandeh et al. [92]	WBH (Aquatherm) + CTx, 41.8 °C for 1 h. Period of time: ni	n = 1. Pleural mesothelioma	PR: n = 1
Sagowski et al. [93]	WBH (Enthermics, RHS-7500) + CTx, 41.8 °C for 60 min. Period of time: ni	n = 1. Squamous cell carcinoma of oral cavity	PR: n = 1
Jeung et al. [94]	EH (Oncotherm EHY2000 +) + CTx or RTx, or EH as monotherapy than combination not feasible, 60 min. 2∼3 times/week, 12 times in one cycle Average number of treatments: 33 sessions in 4 cycles. Period of time: Start: December 2011 and summarized results until September 2012	Included: n = 216, chosen 16 cases characteristically shown. Mixed cancer diagnosis	Different results for each case. In most of the reported cases: good response results
Yeo et al. [95]	EH (Oncotherm EHY2000) + RTx, 60 min, 2 sessions per week, for a total of 12 sessions. Period of time: ni	n = 1. Non-small-cell Lung cancer	CR: n = 1
Outcome: Temperature
Sagowski et al. [93]	WBH (Enthermics, RHS-7500) + CTx, 41.8 °C for 60 min. Period of time: ni	n = 1. Squamous cell carcinoma of oral cavity	With latency of 10 min, increase of intra-tumoural temperature in oral cavity, maximum: 41.8 °C, comparable to esophageal and rectal temperatures
Outcome: Tumour oxygenation
Sagowski et al. [93]	WBH (Enthermics, RHS-7500) + CTx, 41.8 °C for 60 min. Period of time: ni	n = 1. Squamous cell carcinoma of oral cavity	Average increase >  = 100% in each cycle, also significantly improved in tumour in head and neck area despite the fact that this area outside hyperthermia chamber
Pereira Arias et al. [96]	WBH (Aquatherm) + CTx, 41.8 °C for 1 h. Period of time: first treatment: 22th April 1997, died 2th May 1997	n = 1. Leiomyosarcoma of uterus	After treatment: recovery within 2 days: full consciousness, could be extubated, inotropic support stopped and creatinine returned to pre-treatment levels. All cultures remained sterile. After almost complete recovery, 5 days later, second episode of fever during neutropenia and, despite antibiotic treatment, died of sepsis
Feyerabend et al. [97]	ECC-WBH (Parks and Smith) + CTx, 41.8 °C for 60 min. Period of time: ni	n = 1. Embryonal testicular cancer	After > 5 years of follow up, patient alive and disease-free, patient refused further therapy as well as follow-up examinations

CR complete response; CTx chemotherapy; ECC-WBH extracorporeal WBH; EH electro hyperthermia; n number of patients; ni no information; OS overall survival; PR partial response; QoL Quality of Life; RTx radiotherapy; ST survival time; Temp. temperature; WBH whole-body-hyperthermia; WHO World-Health-Organization