Table 7.
Characteristics of studies with multiple intervention
| Reference | Study type | Type of cancer | Multiple interventions |
|---|---|---|---|
| Aschhoff et al. [98] | Single-arm | Prostate cancer | EH + Ukrain |
| Bremer et al. [99] | Single-arm | Breast-, ovarian-, and colorectal cancer | WBH + CTx + hyperoxemia + hyperglycaemia |
| DeCesaris et al. [100] | Case report | Cutaneous squamous cell carcinoma | Cetuximab + RTx + EH |
| Douwes et al. [101] | Single-arm | Ovarian cancer | WBH + CTx + hyperglycaemia |
| Fiorentini et al. [102] | Cohort study | Pancreatic cancer |
Group A: EH (n = 39), subgroup A1: EH + CTX (n = 32), subgroup A2: EH alone: (n = 7) Group B: no EH (n = 67), subgroup B1: CTx: (n = 36), subgroup B2: supportive care (vitamins, analgesics, parenteral nutrition, acupuncture, and phytotherapy) (n = 31) (Exclusion, because no demographic data for the subgroups) |
| Hager et al. [103] | Single-arm | Colorectal cancer | EH + unspecific immunotherapy: thymus peptides, lectins and enzymes |
| Hager et al. [104] | Case series | Pancreatic carcinoma | EH + complementary treatments |
| Hildebrandt et al. [105] | Case report | Germ cell tumor | WBH + CTx + hyperoxemia + hyperglycaemia |
| Hildebrandt et al. [106] | Unclear | Metastatic colorectal cancer | WBH + CTx + hyperoxemia + hyperglycaemia |
| Holzhauer et al. [107] | Case report | Bone and hepatic metastasizing prostate cancer | EH + CTx + several other complementary methods |
| Iyikesici et al. [108] | Single-arm | Non-small cell lung cancer | CTx + ketogenic diet + EH + hyperbaric oxygen therapy |
| Iyikesici et al. [109] | Single-arm | Gastric cancer | CTx + ketogenic diet + EH + hyperbaric oxygen therapy |
| Iyikesici et al. [110] | Single-arm | Metastatic pancreatic cancer | CTx + hyperbaric oxygen therapy + EH |
| Jun et al. [111] | Single-arm | Different entities of cancer | EH + Gun-Chil Jung capsule |
| Kerner et al. [112] | Single-arm | Colorectal cancer, germ cell tumour, ovarian cancer, cervix cancer, lymphoma | WBH + CTx + hyperoxemia + hyperglycaemia |
| Kleef et al. [113] | Case report | Ovarian cancer | EH + CTx + dendritic cells |
| Kleef et al. [114] | Case series | Different entities of cancer | Ipilimumab + nivolumab + Interleucin-2 + EH or WBH + high dose vitamin C intravenously + alpha lipoic acid |
| Ko et al. [115] | Cohort study | Different entities of cancer | EH + RTx + different combination of surgery, immunotherapy, CTx, hormone therapy (not comparable) |
| Koike et al. [116] | Single-arm | Metastatic lymph nodes of oral squamous cell carcinoma | Retrograde superselective intra-arterial CTx + surgery + EH |
| Krasny et al. [117] | Cohort | Renal carcinoma | Different combinations of WBH + surgery + CTx + hyperglycaemia (not comparable) |
| Lee et al. [118] | Case report | Breast leiomyosarcoma | EH + Pazopanib |
| Nagata et al. (2021) [119] | Case series | Breast cancer | Different combinations of: hormonal therapy, RTx, surgery, various CTx, targeted molecular treatment, EH |
| Nozato et al. [120] | Single-arm | Metastatic lymph nodes of squamous cell carcinoma | Retrograde superselective intra-arterial CTx + EH + surgery |
| Ou et al. [121] | Single-arm | Non-small cell lung cancer | EH + intravenous ascorbic acid |
| Ou et al. [122] | RCT | Non-small lung cancer |
Arm A: intravenous Vit C + EH + best supportive care Arm B: best supportive care alone |
| Pang et al. [123] | RCT | Peritoneal carcinomatosis with malignant ascites |
Group A: EH + TCM (traditional Chinese medicine), n = 130 Group B: intraperitoneal CTx, n = 130 |
| Qiao et al. [124] | Cohort study | Different entities of cancer | Different combination of autologous adoptive cell therapy + CTx + anti-PD-1 antibody + EH |
| Ranieri et al. [125] | Single-arm | Metastatic Colon Cancer | Bevacizumab + CTx + EH |
| Robins et al. [126] | Single-arm | Different entities of cancer | WBH + IFN (interferon) |
| Robins et al. [127] | Single-arm | Different entities of cancer | WBH + CTx + TNF α (tumour-necrosis-factor) |
| Roussakow et al. [128] | Retrospective cohort | Glioma | Different combinations of EH + supportive treatments: mistletoe, selenium, boswellia caterii (not comparable) |
| Rubovszky et al. [129] | Case report | Non-small cell lung cancer | WBH + CTx + Bevacizumab |
| Sahinbas et al. [130] | Case series | Glioma | EH + CTx + RTx + supportive treatments: mistletoe, selenium, boswellia caterii |
| Sakuma et al. [131] | Case report | Carcinoma of the buccal mucosa | Superselective intra-arterial CTx + EH + CTx + cetuximab |
| Sawai et al. [132] | Case report | Breast cancer | CTx + RTx + EH + hormone therapy |
| Scheer et al. [133] | Single-arm | Desmoplastic small round cell tumours | Different combinations of CTx, RTx, autologous stem cell rescue, EH, HIPEC (hyperthermic intraperitoneal CTx) |
| Schencking et al. [134] | Case report | Metastases of breast cancer in lumbar spine | WBH + analgesics + several other therapies |
| Wehner et al. [135] | Single-arm | Different entities of cancer | WBH + CTx + hyperoxemia + hyperglycaemia |
| Weingartner et al. [136] | Case series | Head and neck squamous cell carcinoma | RTx + some patients CTx + two patients cetuximab or nivolumab |
| Wust et al. [137] | Single-arm | Metastatic colorectal cancer | WBH + CTx + hyperoxemia + hyperglycaemia |
| Yu et al. [138] | Single-arm | Hepatocellular carcinoma | EH + RTx + TACE (transcatheter arterial chemoembolization) |
| Yu et al. [139] | Single-arm | Hepatocellular carcinoma | EH + RTx + TACE (transcatheter arterial chemoembolization) |
| Zheng et al. [140] | Case report | Ovarian cancer | Poly-ADP-ribose-polymerase + CTx + EH |
CTx chemotherapy; ECC-WBH WBH with extracorporeal circulation; EH electro hyperthermia; h hour; n number of patients; RCT randomized controlled trial; RTx radiotherapy; WBH whole-body-hyperthermia