Table 1.
Advisory Committee on Immunization Practices contraindications to using ACAM2000® and JYNNEOSTM smallpox vaccines in laboratory and healthcare personnel at risk for occupational exposures to orthopoxviruses
| Contraindication | Primary vaccinees (ACAM2000®) | Revaccinees (ACAM2000®) | Household contactsa (ACAM2000®) | JYNNEOSTM |
|---|---|---|---|---|
| History or presence of atopic dermatitis | X | X | X | |
| Other active exfoliative skin conditions | X | X | X | |
| Conditions associated with immunosuppression | X | X | X | |
| Pregnancy | X | X | X | |
| Aged < 1 year | X | X | X | |
| Breastfeeding | X | X | ||
| Serious vaccine component allergy | X | X | X | |
| Known underlying heart disease (e.g., coronary artery disease or cardiomyopathy) | X | X | ||
| Three or more known major cardiac risk factors | X |
aHousehold contacts include persons with prolonged intimate contact with the potential vaccinee (e.g., sexual contacts) and others who might have direct contact with the vaccination site or with potentially contaminated materials (e.g., dressings or clothing)