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. 2022 Jun 15;24(6):e36004. doi: 10.2196/36004

Table 1.

Summary of results.

Study, year Results
An et al, 2013 [18]

Targeted disorder Substance use (smoking)

Subjects for each study condition, n Nonclinician, 456; unguided, 473; control; 476

Effectiveness outcome (30-day smoking abstinence), % Nonclinician, 14%; unguided, 11%; control, 9%
Arjadi et al, 2018 [19]

Targeted disorder Depression

Subjects for each study condition, n Nonclinician, 159; control, 154

Effectiveness outcome (Patient Health Questionnaire-9 score), mean (SD) Nonclinician, 8.5 (5.74); control, 10.83 (6.21)
Day et al, 2013 [20]

Targeted disorder Depression

Subjects for each study condition, n Nonclinician, 33; control (delayed access), 33

Effectiveness outcome (Depression, Anxiety and Stress Scale depression score), mean (SD) Nonclinician, 10.43 (4.49); control, 14.6 (9.51)

Adherence outcome (completion of all modules), % Nonclinician, 61%; control, N/Aa (adherence outcomes unreported)

Process outcome Usefulness

Results The average usefulness rating of the overall modules was 6.78/10 (ranging from 1, “not useful at all,” to 10, “extremely useful”).
Dirkse et al, 2020 [21]

Targeted disorder Depression

Subjects for each study condition, n Nonclinician, 41; unguided, 42

Effectiveness outcome (Patient Health Questionnaire-9 score), mean (SD) Nonclinician, 4.83 (2.7); unguided, 5.51 (4.5)

Adherence outcome (completion of all modules), % Nonclinician, 93%; unguided, 81%

Process outcome Satisfaction

Results A total of 85% of unguided and 90% of nonclinician-guided participants were either “satisfied” or “very satisfied” with the course (no significant difference), 93% of unguided and 100% of nonclinician-guided participants were either “satisfied” or “very satisfied” with the quality of the lessons and the materials (no significant difference); nonclinician-guided participants had significantly higher levels of satisfaction with the level of support, though both groups had relatively high satisfaction (96% of participants overall were “satisfied” or “very satisfied”).
Farrer et al, 2011 [22]

Targeted disorder Depression

Subjects for each study condition, n Nonclinician, 41; unguided, 38; control, 35

Effectiveness outcome (Center for Epidemiologic Studies Depression Scale score), mean (SD) Nonclinician, 21 (12.4); unguided, 24.4 (13.6); control, 35.1 (13.9)

Adherence outcome (minimum dose: 3/5 modules), % Nonclinician, 37.7%; unguided, 31.6%; control, N/A (received no intervention)

Adherence outcome (completion of all modules), % Nonclinician, 17.8%; unguided, 15.8%; control, N/A (received no intervention)
Flynn et al, 2020 [23]

Targeted disorder Mental well-being

Subjects for each study condition, n Nonclinician, 30; unguided, 30

Effectiveness outcome (Warwick-Edinburgh Mental Wellbeing Scale score), mean (SD) Nonclinician, 48.43 (12.66); unguided, 42.88 (9.66)

Adherence outcome (completion of all modules), % Nonclinician, 52%; unguided, 43%
Heber et al, 2016 [24]

Targeted disorder Stress

Subjects for each study condition, n Nonclinician, 132; control (delayed access), 132

Effectiveness outcome (Perceived Stress Scale-10 score), mean (SD) Nonclinician, 17.88 (6.17); control, 22.96 (6.07)

Adherence outcome (completion of all modules), % Nonclinician, 70.5%; control, N/A (adherence outcomes unreported)

Process outcome Satisfaction

Results A total of 92.2% of participants were “satisfied in an overall, general sense” (ie, either “very satisfied” or “mostly satisfied”).
Kobak et al, 2015 [25]

Targeted disorder Obsessive compulsive disorder

Subjects for each study condition, n Clinician, 31; nonclinician, 28; unguided, 28

Effectiveness outcome (Yale Brown Obsessive Compulsive Scale score), mean (SD) Clinician, 15.32 (7.04); nonclinician, 15.61 (5.88); unguided, 16.32 (6.97)

Process outcomes Satisfaction, usability

Results A total of 98% of participants “agreed” or “strongly agreed” with the statement that “they were satisfied with bt steps.” For usability, the mean total system usability score was 83.5/100 (between “good” and “excellent”).
Possemato et al, 2019b [26]

Targeted disorder Posttraumatic stress disorder and hazardous drinking

Subjects for each study condition, n Nonclinician, 15; unguided, 15

Effectiveness outcome (Posttraumatic Stress Disorder Checklist—Military score), mean (SD) Nonclinician, 41.78 (14.90); unguided, 43.16 (13.42)

Process outcome Satisfaction

Results A total of 78% of participants were “very satisfied.”
Proudfoot et al, 2012 [27]

Targeted disorder Bipolar disorder (perception of illness)

Subjects for each study condition, n Nonclinician, 139; unguided, 141; control, 139

Adherence outcome (minimum dose; 4/8 module workbooks) Nonclinician, 79.9%; unguided, 69.1%; control, N/A (received no intervention)

Adherence outcome (completion of all modules) 38.8% across 3 groups
Robinson et al, 2010 [28]

Targeted disorder Generalized anxiety disorder

Subjects for each study condition, n Clinician, 47; nonclinician, 50; control (delayed access), 48

Effectiveness outcome (General Anxiety Disorder-7 score), mean (SD) Clinician, 5.55 (4.73); nonclinician, 6.02 (3.43); control, 11.25 (4.70)

Adherence outcome (completion of all modules), % Clinician, 74%, nonclinician, 80%; control, N/A (received no intervention)

Process outcome Satisfaction

Results A total of 87% of participants in the nonclinician-guided and clinician-guided groups were either “very satisfied” or “mostly satisfied” with the overall program (no significant difference).
Rosso et al, 2017 [29]

Targeted disorder Depression

Subjects for each study condition, n Nonclinician, 37; control, 40

Effectiveness outcome (Hamilton Depression Rating Scale-17 score), mean (SD) Nonclinician, 9.17 (6.92), control, 14.05 (5.34)

Adherence outcome (completion of all modules), % Nonclinician, 92%; control, 75%
Titov et al, 2010 [30]

Targeted disorder Depression

Subjects for each study condition, n Clinician, 46; nonclinician, 41; control, 40

Effectiveness outcome (Beck Depression Inventory-II score), mean (SD) Clinician, 14.59 (11.12); nonclinician, 15.29 (9.81); control, 26.15 (10.14)

Adherence outcome (completion of all modules), % Clinician, 80%; nonclinician, 80%; control, N/A (adherence outcomes unreported)

Process outcome Satisfaction

Results A total of 87% of participants in the nonclinician-guided or clinician-guided groups were either “very satisfied” or “mostly satisfied” with the overall program (no significant difference).

aN/A: not applicable.

bPossemato reported a nonclinician intervention retention rate of 93% and unguided intervention retention rate of 73% but did not define “intervention retention.”