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. 2022 Jun 29;10(6):e003811. doi: 10.1136/jitc-2021-003811

Figure 4.

Figure 4

Chronological serum cytokine level in six patients who received 5×109 TBI-1301 cells. (A) Serum IL-6, IFN-γ, TNF-α, and IL-2 levels in three patients with CRS. (B) Cytokine levels in three patients without CRS. (C) Multiple cytokines levels measured by Bio-Plex Pro human cytokine screening 48-Plex panel in three patients with CRS. (D) Cytokine levels in two patients without CRS. The serum sample from patient no 7 was unavailable. (E) Cytokine levels in the supernatants of TBI-1301 products from six patients after culturing with NY-ESO-1 peptide–pulsed target cells. Data from patients with CRS are shown on the left and those from patients without CRS are on the right. (F) Cytokine profiles responding to NY-ESO-1-peptide stimulation of TBI-1301 manufactured products in patients with and without CRS. CRS, cytokine release syndrome; IFN-γ, interferon gamma; IL, interleukin; TBI-1301, TCR-transduced T cell product; TNF-α, tumor necrosis factor alpha.