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. 2022 Jun 16;14:904895. doi: 10.3389/fnagi.2022.904895

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Copyright © 2022 Shokouhi, Khodakarami, Fernando, Osborn and Horne.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Panel (A) shows the average daily step count (y-axis) of C_LPER, C_HPER, PwP_LPER, and PwP_HPER participants. Panel (B) compares the average daily step count (y-axis) of C_LPER, all PwP_LPER, PwP_LPER stratified according to the PKG’s score for bradykinesia (mBKS) in the shade areas and PwP_HPER. Note that the distribution of PwPLPRE with mBKS ≤ 25 has a similar distribution to that of C_LPER, whereas those with the highest mBKS have a distribution similar to PwP_HPER. Panel (C) shows the average time spent each day in long walks (walks > 1 min, y-axis) of C_LPER, C_HPER, PwP_LPER, and PwP_HPER participants. Panel (D) shows the change (Δ) in average step count from before treatment to after treatment (y-axis: a positive number indicates an increase in step count). PwP_LPRE were sorted into three categories based on change (Δ) in mBKS from before treatment to after treatment where a negative (Δ) indicates an improvement in mBKS (and bradykinesia). All plots are box (median, 25th, 75th percentiles) and whiskers (10th and 90th percentiles) plots. The statistical differences between relevant plots are shown by p-values obtained from an ANOVA and Šídák’s multiple-comparisons post hoc test.