Table 1. Patient Clinical and Procedural Characteristicsa.
| Characteristic | Participants, No. (%) | P value | |
|---|---|---|---|
| Plasma (n = 49) | PCC (n = 51) | ||
| Age at surgery, median (IQR), y | 69 (59-75) | 70 (62-78) | .44 |
| Female | 14 (28.6) | 25 (49.0) | .04 |
| Male | 35 (71.4) | 26 (51.0) | |
| BMI, median (IQR) | 28.9 (25.9-32.8) | 28.7 (24.4-32.6) | .44 |
| Medical history | |||
| Cerebrovascular accident | 1 (2.0) | 1 (2.0) | >.99 |
| Vascular thromboembolic disease | 0 | 0 | NA |
| Atrial fibrillation | 0 | 6 (11.8) | .03 |
| eGFR <60 mL/min/1.73 m2 | 2 (4.1) | 0 | .24 |
| Prior sternotomy | 27 (55.1) | 28 (54.9) | >.99 |
| Procedure performed | |||
| Aortic replacement | 6 (12.2) | 8 (15.7) | .50 |
| Multivalve repair or replacement | 15 (30.6) | 10 (19.6) | |
| Valve repair or replacement plus CABG | 8 (16.3) | 13 (25.5) | |
| Single valve | 6 (12.2) | 8 (15.7) | |
| Aortic replacement plus valve repair or replacement | 11 (22.4) | 10 (19.6) | |
| Aortic replacement plus CABG | 0 | 1 (2.0) | |
| Congenital defect repair | 1 (2.0) | 0 | |
| Pericardiectomy | 2 (4.1) | 0 | |
| CABG | 0 | 1 (2.0) | |
| Deep hypothermic circulatory arrest | 11 (22.4) | 16 (31.4) | .37 |
| Intraoperative antifibrinolytic | 49 (100) | 51 (100) | NA |
| CPB time, median (IQR), min | 155 (120-203) | 161 (116-215) | .94 |
| Any cross-clamp use | 44 (89.8) | 47 (92.2) | .74 |
| Cross-clamp time, median (IQR), minb | 117 (85-165) | 114 (84-158) | .77 |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); CABG, coronary artery bypass grafting; CPB, cardiopulmonary bypass; eGFR, estmated glomerular filtration rate; NA, not applicable; PCC, prothrombin complex concentrate.
a
Continuous variables are summarized using median (IQR) and compared between groups using the rank sum test. Categorical variables are summarized using No. (%) and compared between groups using the Fisher exact test.
b
Cross-clamp time is summarized for patients who required cross-clamp use (n = 44 and n = 47 for the plasma and PCC groups, respectively).