TABLE 2.

Pyroptosis in AD.

Works	Key molecules	Summary
Tan et al. (2014)	Aβ, NLRP1, IL-1β	Aβ deposition increased NLRP1. Inhibiting NLRP1 decreased caspase-1 and IL-1β.
Wu et al. (2013)	Aβ, NLRP3, IL-1β	In Microglial, IL-1β was activated through Aβ/caspase-1/NLRP3 pathway.
Yap et al. (2019)	Aβ	Aβ deposition activated inflammasome, and then cleaved caspase-1 triggering pyroptosis.
Venegas et al. (2017)	Aβ	ASC bound to Aβ, resulting in the formation of Aβ oligomers and aggregates.
Li J. et al. (2020)	Aβ, GSDMD	Inhibiting NLRP3 reduced pyroptosis and decreased NLRP3, caspase-1, GSDMD.
Han et al. (2020)	Aβ, GSDMD	Aβ1-42 induced pyroptosis through NlRP3/caspase-1/GSDMD signaling pathway.
Heneka et al. (2013)	Aβ, GSDMD	Aβ deposition induced NLRP3 inflammasome. NLRP3 reduction decreased caspase-1 and GSDMD.
Li et al. (2021)	GSDMD	Guanidine reduced hippocampal neuron damage by inhibiting GSDMD mediated pyroptosis.
Lei et al. (2021)	Caspase-8, GSDME	Hippocampal injured through caspase-8/GSDME pyroptosis pathway.
Liu (2020)	GSDME	Hippocampal CA3 region was found neuronal degeneration and cell death with increased GSDME positive cells.
Feng et al. (2021)	Tau protein, IL-1β	IL-1β induced microglial phagocytic activity loss, and tau protein hyperphosphorylation.
Ising et al. (2019)	Tau protein, NLRP3	NLRP3 induced tau protein hyperphosphorylation and aggregation.
Li Y. et al. (2020)	Tau protein, caspase-1	Injecting caspase-1 inhibitor or lithium chloride suppressed tau protein hyperphosphorylation and pyroptosis.
Saresella et al. (2016)	NLRP1, IL-1β, IL-18	NLRP1/caspase-1/ILs pathway activated in AD brain.
Ojala et al. (2009)	Inflammatory cytokines	IL-1, IL-1β and IL-18 expression was increased in AD brain.