TABLE 2.
Animal experiments on the relationship between inflammation in peripheral organs and in the brain.
| Research | Disease model and Mehod | Animal | Neuropsychiatric symptoms | Affected regions |
| Furutama et al. (2020) | Periodontal disease (PD) | C57BL/6J mice (8- to 12-week-old females) | Neurodegenerative disorder | Hippocampus |
| Albaret et al. (2020) | Gastritis | C57BL/6 mice (6-week-old females) | Alzheimer’s disease (AD) | Not mentioned |
| Lin et al. (2018) | pancreatitis | Adult male Sprague Dawley rats | Not mentioned | Not mentioned |
| Matsushita et al. (2021) | Arthritis | DBA/1J mice (Male) | Fatigue, depression, hyperalgesia | Area postrema (AP) |
| Ding et al. (2020) | Cystitis | Adult female Sprague Dawley rats | Pathological pain | Not mentioned |
| Han et al. (2020) | Cystitis | Adult female Sprague Dawley rats | Mechanical allodynia, depressive-like behaviors, and memory deficits | Hippocampus |
| Shin et al. (2021) | Atopic dermatitis | BALB/CJ mice (9-week-old pregnant female) | Autism | Not mentioned |