Figure 2.

Univariate Cox regression model evaluating factors associated with investigator-assessed progression-free survival (positron emission tomography intent-to-treat population; n=1,305). Total metabolic tumor volume (TMTV) high defined as ≥366 cm³ and TMTV low defined as <366 cm³; TLG high defined as ≥ median total lesion glycolysis (TLG) and TLG low defined as <median TLG. CI: confidence interval; ECOG PS: Eastern Cooperative Oncology Group performance status; IPI: International Prognostic Index; LDH: lactate dehydrogenase; SPD: sum of products of diameters of up to 6 target lesions.