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Localization of the 5-LO in the in CFBE41o- cell line. (A) Intracellular localization of the 5-LO in CFBE41o- cell line expressing WT CFTR and F508del CFTR grown on glass coverslips. (B) Effect of ionomycin and BAPTA-AM on the 5-LO localization evaluated by the quantification of the nucleus/cytoplasmic ratio of 5-LO staining. *p < 0.05 and ****p < 0.0001.
