Figure 3.
Docosahexaenoic acid (DHA) metabolites biosynthesis. (A) Schematic illustration of the D-series of resolvins (RvD), protectins (PD) and maresins (MaR) biosynthesis’ pathway showing the enzymes involved, 5-LO, 15-LO and 12-LO as well as their intermediates substrates 17-HDOHEand 14-HDOHE. (B) Comparison of the mean levels of each DHA metabolite (RvD2, rvD3, RvD4, RvD5, PD1 and 17-HDOHE) between samples derived from non-CF and CF subjects (top) and from male and female CF patients (bottom). (Mann-Whitney test. *p<0.05), **p<0.01).