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Eicosapentaenoic acid metabolism (EPA) metabolites biosynthesis. (A) Schematic illustration of the E-series of resolvins (RvE) biosynthesis’ pathway showing the enzymes involved, 5-LO, 15-LO, 12-LO and their intermediates substrates, the 18-hydroxyeicosapentaenoic acid (18HEPE). (B) Comparison of the mean levels of the EPA metabolite RvE3 between samples derived from non-CF and CF subjects (left) and from male and female CF patients (right). (Mann-Whitney test. *p<0.05).
