Table 5.
Case-fatality rate (CFR) in patients ≥ 80 years of age hospitalized with COVID-19
| No. of deaths/Total No. of Patients | % of total deaths | CFR % | OR (95% CI) | p value | |
|---|---|---|---|---|---|
| Total | |||||
| 80–84 years | 818/2271 | 33.1 | 36.0 | Ref | |
| 85–90 years | 921/2106 | 37.2 | 43.7 | 1.38 (1.22–1.55) | < 0.001 |
| 90–94 years | 538/1185 | 21.8 | 45.4 | 1.47 (1.38–1.70) | < 0.001 |
| ≥ 95 years | 196/391 | 7.9 | 50.1 | 1.78 (1.43–2.21) | < 0.001 |
| Total | 2473/5953 | 100 | 41.5 | ||
| First wave | |||||
| 80–84 years | 685/1772 | 34.2 | 38.7 | Ref | |
| 85–90 years | 750/1622 | 37.4 | 46.2 | 1.36 (1.19–1.56) | < 0.001 |
| 90–94 years | 413/864 | 20.6 | 47.8 | 1.45 (1.23–1.71) | < 0.001 |
| ≥ 95 years | 156/287 | 7.8 | 54.4 | 1.89 (1.47–2.42) | < 0.001 |
| Total | 2004/4545 | 100 | 44.1 | ||
| Successive waves | |||||
| 80–84 years | 133/499 | 28.4 | 26.7 | Ref | |
| 85–90 years | 171/484 | 36.5 | 35.3 | 1.50 (1.14–1.97) | 0.003 |
| 90–94 years | 125/321 | 26.7 | 38.9 | 1.75 (1.30–2.37) | < 0.001 |
| ≥ 95 years | 40/104 | 8.5 | 38.5 | 1.72 1.10–2.67) | 0.016 |
| Total | 469/1408 | 100 | 33.3 | - | |
| Differences between first and successive waves* | 95% (CI)* | p value** | |||
| 80–84 years | - | - | - | -12.0 (-7.4; -16.4) | < 0.001 |
| 85–90 years | - | - | - | -10.9 (-5.9; -13.2) | < 0.001 |
| 90–94 years | - | - | - | -8.9 (-2.5, -15.0) | 0.006 |
| ≥ 95 years | - | - | - | -15.8 (-4.7; -26.3) | < 0.001 |
| Total | - | - | - | -10.8 (-7.9; -13.6) | < 0.001 |
*The confidence intervals for differences between CFR in the first wave and successive waves were calculated using the methods of Newcombe et al. ** Significance of differences between the first and successive wave was calculated using the two proportion z-test
OR Odds ratio, CI confidence interval
Statistically significant differences are indicated in bold