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. 2022 Jun 30;5:83. doi: 10.1038/s41746-022-00627-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The analysis indicates that EIDD-1931 interacts differently with remdesivir (RDV) and baricitinib (BRT). EIDD-1931/remdesivir interaction surface had a convex shape indicating a synergistic interaction, while EIDD-1931/baricitinib interaction surface had a concave shape indicating a dose-dependent, mildly antagonistic interaction. L0, L1, and L2 correspond to concentration Level 0, Level 1, and Level 2.