Table 2.
Clinically actionable drug concentrations for the IDentif.AI-x drug combination optimization.
| Drug | Level 0 (μM) | Level 1 (μM) | Level 2 (μM) |
|---|---|---|---|
| RDV | 0 | 0.185 | 0.370 |
| EBS | 0 | 0.000068 | 0.000136 |
| MST | 0 | 0.026 | 0.053 |
| IMT | 0 | 0.136 | 0.272 |
| BRT | 0 | 0.007 | 0.014 |
| EIDD-1931 | 0 | 0.315 | 0.458 |
Concentration Level 0 indicated a lack of the drug, concentration Level 1 and Level 2 were selected based on 5% and 10% Cmax for RDV, EBS, MST, IMT, and BRT. Concentration Level 1 and Level 2 were selected based on absolute EC10 and absolute EC20 for EIDD-1931.
Remdesivir (RDV), ebselen (EBS), masitinib (MST), imatinib mesylate (IMT), baricitinib (BRT).