Figure 1.
Expression of PDE5A in EAC patient samples compared with normal esophagus
(A) Expression of PDE5A in the Wang et al. dataset.30PDE5A is overexpressed in Barrett’s esophagus (BE, n = 20), esophageal adenocarcinoma (EAC, n = 21), and esophageal squamous cell carcinoma (ESCC, n = 9) compared with normal squamous epithelium (NSE, n = 19).
(B) Expression of PDE5A in the Krause et al. dataset.31PDE5A is overexpressed in BE (n = 5) and EAC (n = 48) compared with normal adjacent epithelium (NAE, n = 18).
(C) Expression of PDE5A in RNA-sequencing data from the TCGA and GTEx projects analyzed through Xena.35PDE5A is overexpressed in EAC (n = 85) from TCGA compared with NSE (n = 269) from GTEx. ∗∗∗∗p < 0.0001.
(D) PDE5A expression is associated with worse overall survival in EAC patients (n = 52) in Peters et al.34
Log2-transformed counts data were extracted and comparative analysis was performed using a Welch’s t test. Box and whisker plots represent the IQR of log2 expression of PDE5A. Central line = median, outliers are individual points outside of whiskers.