| Vardenafil | Required dose | Given to mice |
|---|---|---|
| Low dose (cycle 1) | 4 mg/kg | 4 mg/kg once daily |
| High dose (cycle 2) | 12 mg/kg | 6 mg/kg twice daily (am/pm) |
| Maximum dose (cycle 3) | 16 mg/kg | 8 mg/kg twice daily (am/pm) |
| Tadalafil | Required dose | Given to mice |
| Low dose (cycle 1) | 4 mg/kg | 4 mg/kg once daily |
| High dose (cycle 2) | 8 mg/kg | 8 mg/kg once daily |
| Maximum dose (cycle 3) | 20 mg/kg | 10 mg/kg twice daily (am/pm) |
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