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. 2022 Jun 21;3(6):100541. doi: 10.1016/j.xcrm.2022.100541

Peak serum concentration of chemotherapy agents in humans

Drug Mean peak serum Reported publications Dose in reference
Epirubicin 4.5μM Cividalli et al.70 50mg/m2
Cisplatin 4.3μM Máthé et al. and Johnsson et al.71,72 60 mg/m2
Fluorouracil/Capecitabine 4.6μM Kolinsky et al.73 200 mg/m2 & 625 mg/m2
Vardenafil 0.0267μM (FDA licensing documentation: https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/021400s010lbl.pdf) 20 mg for ED