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Selectivity of HS-276 in the human kinome. (a) Human kinome wide screening of HS-276 against 140 human kinases. (b) Inhibition of top kinases from kinase screening (% inhibition from control). (c) Kinase inhibition of top 10 kinase hits against HS-276. Data points represent mean ± SEM (n = 2). (d) Inhibition of TAK1 and IRAK4 by HS-276. (e) Dendrogram of human kinase inhibition by HS-276. The sizes of the dots are indicative of kinase activity.
