TABLE 1.

Overview of studies on TNFR1 and TNFR2’s differential processes within the brain.

Study	Study performed	TNFR type	Cell type	Observed effects
(68)	TNFR1 and TNFR2 levels measured in encephalitis mouse model	TNFR1	Striatal Neurons	TNFR1 carries out reparative function of TNF-α on striatum neurons
		TNFR2	Hippocampal neurons	TNFR2 carries out reparative function of TNF-α in hippocampus
(69)	Single nucleotide polymorphisms and associated brain morphology changes	TNFR1	Striatal neurons	TNFR1 responsible for TNF-α regulation of striatal morphology through apoptosis
		TNFR2	Hippocampal neurons	TNFR2 responsible for TNF-α regulation of hippocampal morphology through anti-apoptotic processes
(87)	Anti-TNF-α therapy and its effects on cell survival	TNFR1	Cholinergic neurons	When TNFR1 receptor blocked by anti-TNF-α, reduced apoptosis
		TNFR2	Cholinergic neurons	When TNFR2 blocked by anti-TNF-α, reduced cell protective processes
(88)	TNFR2 KO mice	TNFR2	Microglia	KO mice displayed early onset experimental autoimmune encephalitis
(89)	Activating TNFR2 in cultured mouse microglia	TNFR2	Microglia	TNFR2 regulates production of pro-regenerative and neuroprotective factors such as granulocyte colony-stimulating factor and IL-10

TNF-α, tumor necrosis factor-alpha; TNFR1, TNF-α receptor 1; TNFR2, TNF-α receptor 2; KO, knockout; IL-10, interleukin-10.