Table 3.
Output from P. vivax classifier using IgG antibody responses from (1) top eight P. vivax serological exposure markers and (2) two adjusted panels of eight P. vivax serological exposure markers with low levels of P. knowlesi-cross-reactivity
| Samples | Total N | Classified positive legacy 8, number (%) |
Classified positive modified 8, with RBP2b1986–2653, number (%) |
Classified positive modified 8, with RBP2b161–1454, number (%) |
|---|---|---|---|---|
| ACTKNOW | ||||
| Day 0 | 98 | 47 (48.0%) | 26 (26.5%) | 36 (36.7%) |
| Day 7 | 99 | 81 (81.8%) | 69 (69.7%) | 67 (67.7%) |
| Day 28 | 99 | 68 (68.7%) | 43 (43.4%) | 49 (49.5%) |
| PACKNOW | ||||
| Day 0 | 41 | 21 (51.2%) | 12 (29.3%) | 12 (29.3%) |
| Day 7 | 35 | 27 (77.1%) | 28 (80.0%) | 25 (71.4%) |
| Day 14 | 15 | 11 (73.3%) | 10 (66.7%) | 8 (53.3%) |
| Day 28 | 33 | 20 (60.6%) | 19 (57.8%) | 14 (42.4%) |
| Day 365 | 42 | 7 (16.7%) | 3 (7.1%) | 4 (9.5%) |
A classification of previous exposure was taken when predicted probability was greater than a cut off corresponding to the respective sensitivity and specificity targets of 79% and 79% (legacy), 72.4% and 70.8% (RBP2b1986–2653), or 78.7% and 76.9% (RBP2b161-–1454).