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. 2022 Jun 14;48(2):139. doi: 10.3892/or.2022.8350

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Effects of FANCI knockdown on EMT in NSCLC cells. (A and B) Wound-healing (magnification, ×10) and Transwell assays (magnification, ×20) showed that downregulation of FANCI expression significantly inhibited cell migration and invasion in A549 and H1299 cells. (C) Knockdown of FANCI increased the level of EMT marker E-cadherin but reduced those of N-cadherin and vimentin. *P<0.05, **P<0.01, ***P<0.001. FANCI, Fanconi anemia complementation group I; EMT, epithelial-mesenchymal transition; NSCLC, non-small cell lung cancer; NS, not significant; NC, negative control.