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. 2022 Jun 30;59(6):2101733. doi: 10.1183/13993003.01733-2021

FIGURE 1.

FIGURE 1

Hierarchical cluster analysis (HCA) of metabolite abundances. HCA was performed using multivariate Spearman correlation distance metric and Ward's group linkage. a) Resulting metabolite clusters are presented as a polar dendrogram (differentially coloured and labelled as a to g). Black text: metabolites not significant in either univariate or multivariate analysis; red text: metabolites significant in univariate and/or multivariate analysis. *: p<0.05 univariate analysis; #: p<0.05, canonical variate 1 (CV1) (supplementary figure E1C). b) The mean (95% CI) of log-transformed and z-scaled data of the resulting clusters plotted against the clinical groups. HC: healthy controls; MMA: mild-to-moderate asthma; SAns: severe asthma non-smokers; SAs: severe asthma ex/smokers; L: longitudinal data.