Table 1.
Baseline characteristics of the patients
| Characteristic | PT-INR level quartile | |||||
|---|---|---|---|---|---|---|
| Overall | ≤ 0.96 | 0.96–1.01 | 1.01–1.06 | > 1.06 | p Value | |
| (n = 44,662) | (n = 12,014) | (n = 12,389) | (n = 9936) | (n = 10,323) | ||
| Demographic | ||||||
| Age, year | 62.96 (10.71) | 60.98 (10.15) | 62.31 (10.54) | 63.75 (10.72) | 65.28 (11.01) | < 0.001 |
| Male, n (%) | 33,938 (75.99) | 8583 (71.44) | 9353 (75.49) | 7688 (77.38) | 8314 (80.54) | < 0.001 |
| Medical history | ||||||
| AMI, n (%) | 8544 (19.15) | 1447 (12.06) | 1931 (15.60) | 1973 (19.88) | 3193 (30.98) | < 0.001 |
| CHF, n (%) | 3830 (8.58) | 601 (5.01) | 761 (6.15) | 820 (8.26) | 1648 (15.98) | < 0.001 |
| Hypertension, n (%) | 25,415 (56.98) | 6920 (57.68) | 7021 (56.74) | 5732 (57.76) | 5742 (55.70) | 0.007 |
| DM, n (%) | 12,423 (27.85) | 3582 (29.85) | 3384 (27.35) | 2564 (25.84) | 2893 (28.07) | < 0.001 |
| PCI, n (%) | 33,284 (74.52) | 8746 (72.80) | 9142 (73.79) | 7464 (75.12) | 7932 (76.84) | < 0.001 |
| CKD, n (%) | 7833 (21.56) | 1479 (15.49) | 1803 (18.18) | 1764 (21.77) | 2787 (31.79) | < 0.001 |
| Laboratory test | ||||||
| INR | 1.02 (0.13) | 0.93 (0.03) | 0.99 (0.01) | 1.04 (0.01) | 1.15 (0.20) | < 0.001 |
| D-dimer (ng/mL) | 624.48 (1256.03) | 474.66 (810.95) | 514.92 (863.34) | 605.73 (1116.67) | 949.80 (1956.06) | < 0.001 |
| FIB, g/L | 4.12 (1.28) | 4.03 (1.04) | 4.07 (1.18) | 4.14 (1.31) | 4.26 (1.59) | < 0.001 |
| ALT (U/L) | 34.36 (84.89) | 31.91 (28.61) | 30.99 (54.32) | 30.65 (31.11) | 44.78 (159.84) | < 0.001 |
| AST (U/L) | 48.92 (196.68) | 33.70 (44.46) | 36.43 (55.56) | 42.20 (70.42) | 88.06 (393.12) | < 0.001 |
| WBC, 109/L | 7.97 (2.71) | 7.73 (2.14) | 7.73 (2.31) | 7.84 (2.60) | 8.67 (3.59) | < 0.001 |
| HGB, g/L | 133.13 (16.75) | 136.64 (14.81) | 134.83 (15.58) | 132.29 (16.44) | 127.82 (18.98) | < 0.001 |
| CHOL, mmol/L | 4.54 (1.21) | 4.87 (1.27) | 4.59 (1.18) | 4.41 (1.13) | 4.21 (1.14) | < 0.001 |
| TRIG, mmol/L | 1.67 (1.22) | 2.05 (1.68) | 1.69 (1.11) | 1.53 (0.93) | 1.34 (0.76) | < 0.001 |
| LDLC, mmol/L | 2.80 (0.97) | 2.97 (1.01) | 2.84 (0.97) | 2.73 (0.93) | 2.63 (0.94) | < 0.001 |
| HDLC, mmol/L | 1.00 (0.26) | 1.04 (0.27) | 1.00 (0.25) | 0.98 (0.25) | 0.95 (0.25) | < 0.001 |
| HbA1c, % | 6.56 (1.42) | 6.69 (1.52) | 6.53 (1.38) | 6.51 (1.39) | 6.50 (1.37) | < 0.001 |
| URIC, μmol/L | 393.52 (110.49) | 393.45 (102.21) | 389.57 (102.89) | 390.74 (109.23) | 401.10 (128.07) | < 0.001 |
| eGFR, ml/min/1.73 m2 | 77.95 (25.22) | 82.87 (25.19) | 79.64 (23.69) | 77.33 (24.39) | 71.25 (26.18) | < 0.001 |
| ALB, g/L | 36.37 (4.22) | 37.40 (3.79) | 36.93 (3.88) | 36.31 (4.03) | 34.55 (4.65) | < 0.001 |
| Hs-CRP, mg/L | 12.07(22.75) | 6.24 (11.82) | 8.66 (18.00) | 11.60 (23.36) | 23.40 (40.60) | < 0.001 |
| Medication | ||||||
| Antiplatelet, n (%) | 42,965 (97.41) | 11,606 (97.34) | 11,945 (97.24) | 9596 (97.59) | 9818 (97.54) | 0.318 |
| ACEI/ARB, n (%) | 22,110 (50.13) | 5801 (48.65) | 6130 (49.90) | 4942 (50.26) | 5237 (52.03) | < 0.001 |
| Beta-blockers, n (%) | 35,957 (81.52) | 9804 (82.23) | 10,039 (81.72) | 8008 (81.44) | 8106 (80.53) | 0.012 |
| Statin, n (%) | 42,274 (95.85) | 11,488 (96.35) | 11,812 (96.16) | 9434 (95.94) | 9540 (94.77) | < 0.001 |
| Death, n (%) | 5613 (12.57) | 1116 (9.29) | 1426 (11.51) | 1249 (12.57) | 1822 (17.65) | < 0.001 |
AMI acute myocardial infarction, CHF congestive heart failure, DM diabetes mellitus, PCI percutaneous coronary intervention, CKD chronic kidney disease, WBC white blood cell, HGB hemoglobin, CHOL serum total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C hight-density lipoprotein cholesterol, HbA1c Glycated hemoglobin, eGFR estimated glomerular filtration rate, ALB albumin, Hs-CRP hypersensitive C-reactive protein, ACEI/ARB angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, AST aspartate transaminase, ALT alanine aminotransferase, FIB fibrinogen