Table 2.

Characteristics of patients (n = 449) treated with a Long Acting Injection (LAI) drug, divided in on–label and off–label prescription

	ON LABEL	OFF LABEL	SIG
Diagnosis			p = 0.000
SCZ (n = 331)	331 (100%)	0
Schizophrenia	251 (100%)	0
Schizoaffective disorder	74 (100%)	0
Organic Psychosis	4 (100%)	0
Substance-related psychosis	2 (100%)	0
NO-SCZ (n = 118)	4 (3.4%)	114 (96.6%)
Bipolar Disorder	4 (4.9%)	77 (95.1%)
OCD	0	4 (100%)
Personality disorder	0	27 (100%)
Neurodevelopment disorder	0	4 (100%)
Neurocognitive disorder	0	2 (100%)
Age*	40.97 ± 12.65	44.11 ± 13.18	p = 0.0334
Previous LAI therapy			p = 0.14
Yes (n = 135)	107 (79.3%)	28 (20.7%)
No (n = 314)	228 (72.6%)	86 (27.4%)
Drug category			p = 0.52
FGA (n = 135)	98 (72.6%)	37 (27.4%)
SGA (n = 314)	237 (75.5%)	77 (24.5%)
Gender			p = 0.044
Male (n = 272)	212 (77.9%)	60 (22.1%)
Female (n = 177)	123 (69.5%)	54 (30.5%)
Alcohol			p = 0.021
Yes (n = 65)	41 (63.1%)	24 (36.9%)
No (n = 384)	294 (76.6%)	90 (23.4%)
Substance Misuse			p = 0.26
Yes (n = 90)	63 (70%)	27 (30%)
No (n = 359)	272 (75.8%)	87 (24.2%)
BPRS total*	50.45 ± 14.66	45.12 ± 14.09	p = 0.0013
BPRS anxiety depression*	10.44 ± 4.36	10.88 ± 4.25	p = 0.33
BPRS anergy*	9.83 ± 4.27	8.01 ± 3.56	p = 0.0001
BPRS thought disturbances*	12.88 ± 5.37	9.91 ± 4.89	p = 0.0000
BPRS activation*	7.64 ± 3.35	7.63 ± 3.35	p = 0.91
BPRS hostility*	9.68 ± 4.46	8.69 ± 4.40	p = 0.0474
Kemp’s 7 total*	4.81 ± 1.44	4.74 ± 1.43	p = 0.64
DAI-10 total*	1.78 ± 5.39	2.57 ± 5.24	p = 0.15

SCZ Schizophrenia Spectrum patients, NO-SCZ patients with a diagnosis not included in the schizophrenia spectrum, OCD obsessive compulsive disorder, FGA First Generation Antipsychotic, SGA Second Generation Antipsychotic, SIG significance

All reported values are frequencies, except for *(mean ± standard deviation). In bold p-values below 0.05