Figure 10.

A) Schematic illustrations for i) a backpack and ii) the printing method. B) Confocal images of macrophages (blue, nucleus; green, cytomembrane) displaying backpacks fabricated from PLGA discs (red). C) Schematic illustration of the cellular backpacks for maintaining the proinflammatory phenotype of the adoptive MΦ therapies. a) MΦs stimulated by IFN-γ ex vivo can quickly switch from proinflammatory to antiinflammatory phenotype following penetration through a solid tumor. b) MΦs carrying backpacks loaded with IFN-γ can maintain their proinflammatory phenotype deep within tumor microenvironment, changing the phenotype of the endogenous TAMs. A–C) Reproduced with permission.^[290]