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. 2022 Jun 16;13:880438. doi: 10.3389/fimmu.2022.880438

Figure 3.

Figure 3

uNK upregulate expression of KIR and LILRB1 in first trimester. (A) Uterine and peripheral NK cells taken at different stages of the reproductive cycle were freshly stained for phenotypic markers. Representative staining from CD56dim pNK is shown in blue alongside FMO controls in grey. (B) Graphs showing frequencies of KIR2DL1, KIR2DL2/3, LILRB1 and CD94 on pNK and uNK subsets. Means and standard deviations are shown for n = 8 (menstrual), n = 7 (proliferative), n = 10 (secretory) n= 10 (first trimester), n= 16 (third trimester decidua basalis), n = 16 (third trimester decidua parietalis), n = 4 (postpartum). Statistical testing was done using Kruskal Wallis with a post-hoc Dunn test *p < 0.05, **p < 0.01, ***p < 0.001, ****p< 0.0001. (C) Violin plots showing corresponding mRNA expression in uNK subsets over the reproductive cycle as determined by scRNAseq. M, menstrual phase; P, proliferative phase; S, secretory phase; 1, first trimester; 2, second trimester; 3, third trimester; 3B, third trimester decidua basalis; 3P, third trimester decidua parietalis.