Figure 5.

CSF sTREM2 levels within A/T classification framework with or without CSF α-syn (S) in PD group. CSF sTREM2 was lowest in A-T- group and highest in A-T+ group in PD group (A). CSF sTREM2 was highest in tau pathology in PD-MCI group (B). With the addition of CSF α-syn (S) to A/T framework, CSF sTREM2 was lowest in A+T-S+ group, then higher in A-T-S+ group, and highest in A-T+S- group (C). p-values were assessed by a one-way ANCOVA, and significant p-values after Bonferroni corrected post-hoc pairwise comparisons are marked. CSF, cerebrospinal fluid; sTREM2, soluble triggering receptors expressed on myeloid cells 2; PD, Parkinson's disease; A+, Aβ pathology (defined as low CSF Aβ1–42); T+, tau pathology (defined as high CSF P-tau); S+, α-syn pathology (defined as low CSF α-syn); PD, Parkinson's disease; MCI, mild cognitive impairment.