Table 6.
Advantages and disadvantages of several well-known FF tools.
| Software | Advantage | Disadvantage |
|---|---|---|
| BAYINDIR | Can identify low FF | Y chromosome-specific |
| DEFRAG | Can identify low FF | Y chromosome-specific |
| FetalQuantSD | No parental genotype needed | Needs large number of SNPs |
| NIPTmer | Fast | Does not handle extreme FF values |
| SANEFALCON | Can identify low FF | Non-uniform genome coverage |
| SeqFF | Gold standard, good for both genders | Many false positives |
| WisecondorX | Can use single-end and low coverage data | Exclusive for NIPT |