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. 2022 Jun 16;9:892763. doi: 10.3389/fmolb.2022.892763

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Copyright © 2022 Sarohi, Srivastava and Basak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quantitation of microheterogeneity of K¹⁰¹⁷ site in COL1A1a present in zebrafish heart ECM during regeneration. (A) Chromatogram plots represent the elution of unmodified (K), hydroxylysine (HyK), and glucosylgalactosyl-hydroxylysine (GG-HyK) modified K¹⁰¹⁷ site containing peptide ¹⁰¹¹DGAAGPKGDRGETGPSGTPGAPGPPGAAGPIGPAGK¹⁰⁴⁶ (B) Graphical representation of Skyline-based MS¹ quantitation of micro-heterogenic distribution of unmodified K¹⁰¹⁷ (yellow), HyK¹⁰¹⁷ (green) and GG-HyK277 (blue) species in COL1A1a from the ECM digest of control, 7 DPA, 14 DPA, and 30 DPA regenerating zebrafish heart. The different colors in the bar represent the occupancy of different forms at the K¹⁰¹⁷ site in COL1A1a with mean ± SEM. An increase in glucosylgalactosyl-hydroxylysine levels during regeneration is significant (ANOVA, p < 0.05) (See Table 3)