Table 1.
Source | Number of fibrils | Length (Å) | Number of β-sheets in filaments | Number of filaments in fibril | Twist (deg) |
---|---|---|---|---|---|
13 mM | 16 | 163 to 368 | 4 to 10 | 2 to 5 | −0.18 to −0.73 |
11.5 mM | 9 | 210 to 390 | 5 to 13 | 2 to 6 | −0.23 to −0.85 |
10 mM | 6 | 170 to 415 | 4 to 9 | 2 to 6 | −0.2 to −0.79 |
8.5 mM | 4 | 260 to 515 | 6 to 14 | 2 to 4 | −0.15 to −0.54 |
7 mM | 3 | 435 to 480 | 7 to 17 | 4 to 6 | −0.11 to −0.48 |
7 mM seeded | 3 | 443 to 485 | 13 to 14 | 5 | −0.10 to −0.80 |
ssNMR model | 4 | 2 to 4 | −0.85 | ||
TEM* | 4 | 3 to 8 | −0.71 to −0.81 |
The first six rows indicate fibrils formed in silico in our multi-eGO simulations; ssNMR is for the fibrils corresponding to PDB codes 2M5K, 2M5M, and 3ZPK; and TEM are those observed in vitro in this work.
*Values for TEM are estimates; SI Appendix, Table S2.