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. 2022 Jun 23;119(26):e2203181119. doi: 10.1073/pnas.2203181119

Table 1.

Summary of the main structural features of the fibrils discussed in this work

Source Number of fibrils Length (Å) Number of β-sheets in filaments Number of filaments in fibril Twist (deg)
13 mM 16 163 to 368 4 to 10 2 to 5 −0.18 to −0.73
11.5 mM 9 210 to 390 5 to 13 2 to 6 −0.23 to −0.85
10 mM 6 170 to 415 4 to 9 2 to 6 −0.2 to −0.79
8.5 mM 4 260 to 515 6 to 14 2 to 4 −0.15 to −0.54
7 mM 3 435 to 480 7 to 17 4 to 6 −0.11 to −0.48
7 mM seeded 3 443 to 485 13 to 14 5 −0.10 to −0.80
ssNMR model 4 2 to 4 −0.85
TEM* 4 3 to 8 −0.71 to −0.81

The first six rows indicate fibrils formed in silico in our multi-eGO simulations; ssNMR is for the fibrils corresponding to PDB codes 2M5K, 2M5M, and 3ZPK; and TEM are those observed in vitro in this work.

*Values for TEM are estimates; SI Appendix, Table S2.