Table 2.
Resting Hemodynamics in Upright and Supine Position Within the Main Cohort
| Upright | Supine |
Mean change (95% CI) |
P Value | |
|---|---|---|---|---|
| Overall patients, n=213 | ||||
| Heart rate, bpm | 76±13 | 74±12 | 2.4 (1.5 to 3.3) | <0.001 |
| Systolic blood pressure, mm Hg | 140±20 | 132±18 | 8.1 (6.6 to 9.6) | <0.001 |
| Diastolic blood pressure, mm Hg | 81±15 | 77±11 | 4.3 (2.9 to 5.7) | <0.001 |
| Mean pulmonary artery pressure, mm Hg | 31±14 | 32±13 | −1.0 (−1.6 to −0.4) | <0.001 |
| Pulmonary artery wedge pressure, mm Hg | 11±4 | 12±5 | −1.5 (−1.8 to −1.1) | <0.001 |
| Right atrial pressure, mm Hg | 7±4 | 9±4 | −1.8 (−2.2 to −1.4) | <0.001 |
| Cardiac index, L/min per m2 | 2.9±0.7 | 3.1±0.8 | −0.2 (−0.3 to −0.2) | <0.001 |
| Pulmonary vascular resistance, WU | 4.1±3.1 | 3.9±2.8 | 0.3 (0.1 to 0.5) | <0.001 |
| mPAP/cardiac output, WU | 6.4±4.0 | 6.2±3.5 | 0.3 (0.0 to 0.5) | 0.047 |
| Systemic vascular resistance, WU | 20.4±7.3 | 17.2±5.6 | 3.2 (2.6 to 3.8) | <0.001 |
| Patients with precapillary pulmonary hypertension, n=120 | ||||
| Heart rate, bpm | 78±13 | 74±12 | 3.4 (2.2 to 4.5) | <0.001 |
| Systolic blood pressure, mm Hg | 137±19 | 128±16 | 8.4 (6.3 to 10.4) | <0.001 |
| Diastolic blood pressure, mm Hg | 81±13 | 77±11 | 4.0 (2.1 to 5.9) | <0.001 |
| Mean pulmonary artery pressure, mm Hg | 38±13 | 39±12 | −0.4 (−1.2 to 0.4) | 0.376 |
| Pulmonary artery wedge pressure, mm Hg | 11±4 | 12±4 | −1.0 (−1.5 to −0.5) | <0.001 |
| Right atrial pressure, mm Hg | 8±5 | 10±4 | −1.7 (−2.2 to −1.1) | <0.001 |
| Cardiac index, L/min per m2 | 2.8±0.7 | 3.0±.8 | −0.2 (−0.3 to −0.1) | <0.001 |
| Pulmonary vascular resistance, WU | 5.7±3.4 | 5.3±2.9 | 0.5 (0.2 to 0.7) | <0.001 |
| mPAP/cardiac output, WU | 8.2±4.4 | 7.7±3.5 | 0.5 (0.2 to 0.9) | 0.001 |
| Systemic vascular resistance, WU | 20.7±7.5 | 17.5±5.5 | 3.2 (2.3 to 4.0) | <0.001 |
| Patients with postcapillary pulmonary hypertension n=24 | ||||
| Heart rate, bpm | 75±11 | 75±12 | −0.3 (−2.8 to 2.3) | 0.848 |
| Systolic blood pressure, mm Hg | 146±25 | 141±22 | 4.5 (0.2 to 9.4) | 0.041 |
| Diastolic blood pressure, mm Hg | 78±13 | 75±12 | 3.7 (−0.6 to 8.0) | 0.093 |
| Mean pulmonary artery pressure, mm Hg | 31±9 | 36±8 | −5.1 (−7.0 to −3.3) | <0.001 |
| Pulmonary artery wedge pressure, mm Hg | 15±4 | 19±5 | −4.4 (−5.6 to −3.3) | <0.001 |
| Right atrial pressure, mm Hg | 9±5 | 12±5 | −2.7 (−3.9 to −1.5) | <0.001 |
| Cardiac index, L/min per m2 | 3.0±0.7 | 3.1±0.8 | −0.1 (−0.3 to 0.1) | 0.387 |
| Pulmonary vascular resistance, WU | 2.7±1.2 | 3.2±1.7 | −0.3 (−0.9 to 0.3) | 0.277 |
| mPAP/cardiac output, WU | 5.4±1.6 | 6.9±3.2 | −1.2 (−2.0 to −0.5) | <0.001 |
| Systemic vascular resistance, WU | 18.9±7.0 | 17.5±6.3 | 1.7 (−0.1 to 3.6) | 0.063 |
| Patients with exercise pulmonary hypertension n=38 | ||||
| Heart rate, bpm | 74±11 | 72±11 | 1.8 (−0.3 to 3.8) | 0.088 |
| Systolic blood pressure, mm Hg | 146±19 | 134±22 | 11.8 (8.2 to 15.4) | <0.001 |
| Diastolic blood pressure, mm Hg | 84±22 | 77±10 | 7.0 (3.7 to 10.3) | <0.001 |
| Mean pulmonary artery pressure, mm Hg | 20±4 | 20±3 | 0.1 (−1.4 to 1.5) | 0.943 |
| Pulmonary artery wedge pressure, mm Hg | 9±3 | 9±2 | −0.7 (−1.6 to 0.2) | 0.155 |
| Right atrial pressure, mm Hg | 6±3 | 7±3 | −1.4 (−2.4 to −0.5) | 0.002 |
| Cardiac index, L/min per m2 | 2.9±0.8 | 3.1±0.7 | −0.2 (−0.4 to −0.0) | 0.026 |
| Pulmonary vascular resistance, WU | 2.3±0.9 | 2.0±0.5 | 0.3 (−0.1 to 0.8) | 0.127 |
| mPAP/cardiac output, WU | 4.0±1.1 | 3.7±0.7 | 0.3 (−0.3 to 0.9) | 0.263 |
| Systemic vascular resistance, WU | 21.4±7.4 | 17.6±5.2 | 4.0 (2.5 to 5.4) | <0.001 |
| Patients without pulmonary hypertension, n=31 | ||||
| Heart rate, bpm | 73±12 | 72±12 | 1.54 (−0.7 to 3.8) | 0.176 |
| Systolic blood pressure, mm Hg | 141±15 | 137±16 | 5.0 (1.0 to 9.0) | 0.014 |
| Diastolic blood pressure, mm Hg | 80±9 | 78±9 | 2.7 (−1.0 to 6.4) | 0.147 |
| Mean pulmonary artery pressure, mm Hg | 16±4 | 18±3 | −1.5 (−3.1 to 0.1) | 0.067 |
| Pulmonary artery wedge pressure, mm Hg | 8±3 | 9±3 | −1.8 (−2.8 to −0.8) | <0.001 |
| Right atrial pressure, mm Hg | 6±3 | 8±3 | −1.9 (−2.9 to −0.9) | <0.001 |
| Cardiac index, L/min per m2 | 3.1±0.7 | 3.6±0.8 | −0.5 (−0.7 to −0.3) | <0.001 |
| Pulmonary vascular resistance, WU | 1.6±0.7 | 1.3±0.5 | 0.2 (−0.3 to 0.7) | 0.369 |
| mPAP/cardiac output, WU | 3.1±1.2 | 2.9±0.9 | 0.1 (−0.5 to 0.8) | 0.654 |
| Systemic vascular resistance, WU | 18.8±6.4 | 15.2±5.8 | 3.6 (2.0 to 5.2) | <0.001 |
Values are expressed as means±SD and mean difference (95% CI). mPAP indicates mean pulmonary artery pressure; and WU, Wood units.