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. 2022 Feb 3;11(4):e024561. doi: 10.1161/JAHA.121.024561

Figure 6. Recovery of CRIg+ (complement receptor of the immunoglobulin superfamily) macrophage population attenuates obesity‐associated adrenal dysfunction.

Figure 6

After 4 weeks of injection with lentivirus harboring deactivated Cas9 and guide RNA‐Vsig4, the abundance of bacterial DNA (A), proinflammatory genes (B), cGAS/STING activation (C) in the adrenal glands, circulating catecholamine (D), and systolic blood pressure (SBP) (E) of 16 weeks high‐fat diet (HFD) wild‐type (WT) mice were evaluated. Data are presented as mean±SEM. P values are determined by unpaired 2‐sided Student t test (A through E). Cas9 indicates CRISPR associated protein 9; cGAS, Cyclic GMP–AMP synthase; CRIgoe, overexpressing CRIg; EPI, epinephrine; HSP90, heat shock protein 90; NE, norepinephrine; pSTING, phosphorylated STING; STING, the cyclic GMP–AMP receptor stimulator of interferon genes; and Vsig4, V‐set and immunoglobulin domain containing 4.