Figure 3. Vasoregulation in isolated perfused kidneys of SM‐Agtr1a ^−/− mice.

A and B, Original recordings of the perfusion pressure in kidneys of SM‐Agtr1a ^+/+ (A) and SM‐Agtr1a ^−/− mice (B). C, Increase in perfusion pressure induced by 10 nmol/L Ang II. D, Change of pressure assessed by exposure to Ca²⁺ free PSS. E, Perfusion pressure at flow rates of 0.3, 0.7, 1.3, and 1.9 mL/min. F, Increase in perfusion pressure induced by 60 mmol/L KCl. n=6 SM‐Agtr1a ^+/+ kidneys from 5 mice and n=6 SM‐Agtr1a ^−/− kidneys from 6 mice for all panels. *P<0.05. Ang II indicates angiotensin II; n.s., not significant; PSS, physiological saline solution; SM, smooth muscle; and w.o., washout.