Figure 7. Vasoregulation in isolated perfused kidneys of SM‐Agtr1a ^+/+ mice pretreated with 300 nmol/L G_q/11 blocker FR900359.

A, Original recordings of perfusion pressure in kidneys of Agtr ^+/+ mice in response to various concentrations of Ang II (B) same as (A) but pretreated with 300 nmol/L FR900359 for 30 minutes. C, Increases in perfusion pressure induced by Ang II (1 nmol/L to 1 µmol/L). D, Myogenic tone assessed by exposure of the kidneys to Ca²⁺‐free PSS. E, Increase in perfusion pressure induced by 60 mmol/L KCl. n=15 SM‐Agtr1a ^+/+ kidneys from 12 mice and n=6 SM‐Agtr1a ^+/+ kidneys from 4 mice pretreated with FR900359 for all panels. *P<0.05. Ang II indicates angiotensin II; n.s., not significant; PSS, physiological saline solution; SM, smooth muscle; and w.o., wash‐out.