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Astrocytoma, IDH‐mutant, WHO grade 3. H & E‐stained sections reveal a cellular astrocytic neoplasm (A). Immunohistochemical stains are positive for IDH1 R132H (B) and negative for ATRX (C; loss of nuclear expression). MIB1 (Ki‐67) immunostaining demonstrates an elevated proliferation index (D), consistent with WHO grade 3 classification. (200X magnification)
