TABLE 1.
HSE patient characteristics and Alzheimer's disease‐related pathology
| Patient | Age a | Gender b | Causative virus | Brain regions analyzed | Aβ intraneuronal c | Aβ plaques | NFT |
|---|---|---|---|---|---|---|---|
| 1 | – | – | HSV‐1 | Cortex | No | No | No |
| 2 | 79 | F | HSV‐1 | Hippocampus/cortex | Yes | Yes | Yes |
| Amygdala/entorhinal Cortex | Yes | Yes | Yes | ||||
| Cortex | Yes | Yes | Yes | ||||
| Insula | Yes | Yes | Yes | ||||
| 3 | 0 d | F | HSV‐2 | Cortex | No | No | No |
| 4 | 81 | F | HSV‐1 | Putamen | No | Yes | No |
| 5 | 76 | M | HSV‐1 | Hippocampus/entorhinal cortex | No | Yes | Yes |
Abbreviation: NFT, neurofibrillary tangle.
a
Age in years.
b
F, female; M, male.
c
Intraneuronal Aβ accumulation.
d
Neonatal HSE patient, 2 wk old.