Table 4.

Pharmacokinetic parameters of ROS (10 mg/kg) in the control group and the multiple-dose GLT group (n = 6).

Parameters	Control	GLT (100 mg/kg)	GLT (200 mg/kg)
t1/2 (h)	2.75 ± 0.70	1.99 ± 0.44*	1.68 ± 0.35**
CL/F (mL/h)	13.92 ± 3.04	25.54 ± 9.02*	30.00 ± 8.52**
MRT (h)	3.27 ± 0.65	2.95 ± 1.13	2.13 ± 0.28*
AUC0-t (h·μg/mL)	139.69 ± 45.46	84.58 ± 39.87*	66.60 ± 15.90**
Cmax (μg/mL)	38.72 ± 9.73	28.51 ± 5.56*	28.41 ± 4.64*
Tmax (h)	0.79 ± 0.40	0.54 ± 0.25	0.37 ± 0.13*

*p < 0.05, **p < 0.01, compared with control.