Fig 4. Centrosome growth by localised assembly and distributed disassembly.
(A) Localized assembly around the centriole and disassembly throughout the pericentriolic matter generate a size-dependent disassembly rate which ensures robust size control. (B) Size dynamics of a pair of identical centrosomes that are initialized with equal size. Here Vcell = 5000 μm3 (C) Centrosome volume decreases with increasing centrosome number, nc, during C. elegans embryonic development, where the embryo rapidly divides into many cells with decreasing cell size. Model: solid black line, Experimental data: orange. (D) Centrosome volume, Vc, scales linearly with cell volume, Vcell. Parameters: subunit concentration = 1.67 μM, α = 0, β = 1, subunit size = 5.8 × 10−7 μm3, k+ = 103 μm3min−1, k− = 10−3min−1.