Table 2. Results of multivariable Cox regression for time to suicide attempts (N = 842,773).

Variable	Hazard Ratio	95% CI	p-value
Sex
Men	0.916	(0.862, 0.974)	0.005
Women	1		[Reference]
Age category
26–39 years	0.766	(0.691, 0.849)	<0.001
40–64 years	0.826	(0.755, 0.904)	<0.001
18–25 years	1		[Reference]
Medical conditions
Headache	1.03	(0.951, 1.115)	0.473
Neuropathy	0.63	(0.552, 0.719)	<0.001
Chronic pain	0.652	(0.604, 0.705)	<0.001
Acute pain	0.863	(0.805, 0.924)	<0.001
Cancer	0.454	(0.42, 0.491)	<0.001
Psychiatric conditions
Depression/Bipolar	6.147	(5.736, 6.588)	<0.001
Psychosis	3.634	(3.348, 3.945)	<0.001
Substance Use	2.294	(2.115, 2.487)	<0.001
PTSD	1.452	(1.283, 1.643)	<0.001
Anxiety	0.877	(0.813, 0.946)	0.001
Opioid use (frequency, dose): *
No Use	1		[Reference]
(low, low)	0.742	(0.609, 0.904)	0.003
(low, medium)	0.531	(0.469, 0.601)	<0.001
(low, high)	0.578	(0.471, 0.709)	<0.001
(low, very high)	0.585	(0.323, 1.058)	0.076
(medium, low)	3.344	(2.866, 3.902)	<0.001
(medium, medium)	4.004	(3.618, 4.43)	<0.001
(medium, high)	4.44	(3.707, 5.317)	<0.001
(medium, very high)	2.841	(2.039, 3.96)	<0.001
(high, low)	5.177	(4.268, 6.28)	<0.001
(high, medium)	7.024	(6.182, 7.98)	<0.001
(high, high)	7.231	(6.216, 8.412)	<0.001
(high, very high)	6.712	(5.707, 7.893)	<0.001

* Opioid use frequency is categorized as low (0–1 month/year), medium (1–6 months/year), and high (6–12 months/year); opioid use dose is categorized as low (0–20 MME/day), medium(20–50 MME/day), high (50–100 MME/day) and very high (>100 MME/day).