Table 2. Analysis of the top three GO terms for each organ in mouse and rat using the elevated organ-specific and group-specific canonical proteins as described in the ‘Methods’ section.

Organ	Species	GO ID	Description	adjusted p-value
Articular cartilage	Mus musculus	GO:0030198	Extracellular matrix organization	8.94*10−38
		GO:0043062	Extracellular structure organization	8.94*10−38
		GO:0045229	External encapsulating structure organization	8.94*10−38
Brain	Mus musculus	GO:0050804	Modulation of chemical synaptic transmission	7.03*10−65
		GO:0099177	Regulation of trans-synaptic signalling	7.03*10−65
		GO:0050808	Synapse organization	1.41*10−48
Heart	Mus musculus	GO:0060047	Heart contraction	7.10*10−11
		GO:0008016	Regulation of heart contraction	4.43*10−10
		GO:0060537	Muscle tissue development	6.16*10−10
Kidney	Mus musculus	GO:0015711	Organic anion transport	4.59*10−19
		GO:0044282	Small molecule catabolic process	4.91*10−15
		GO:0016054	Organic acid catabolic process	6.25*10−15
Eye	Mus musculus	GO:0007601	Visual perception	7.54*10−50
		GO:0001654	Eye development	5.31*10−31
		GO:0099504	Synaptic vesicle cycle	8.36*10−18
Liver	Mus musculus	GO:0016569	Covalent chromatin modification	6.26*10−10
		GO:0016570	Histone modification	1.71*10−08
		GO:0019369	Arachidonic acid metabolic process	1.71*10−08
Lung	Mus musculus	GO:0120031	Plasma membrane bounded cell projection assembly	3.61*10−14
		GO:0030031	Cell projection assembly	3.61*10−14
		GO:0044782	Cilium organization	9.83*10−14
Pancreas	Mus musculus	GO:0007586	Digestion	0.005
		GO:0032328	Alanine transport	0.018
Spleen	Mus musculus	GO:0046649	Lymphocyte activation	4.12*10−22
		GO:0050776	Regulation of immune response	2.00*10−20
		GO:0045087	Innate immune response	2.23*10−20
Tendon	Mus musculus	GO:0003012	Muscle system process	1.46*10−25
		GO:0050879	Multicellular organismal movement	3.14*10−19
		GO:0050881	Musculoskeletal movement	1.46*10−25
Testis	Mus musculus	GO:0048232	Male gamete generation	8.75*10−49
		GO:0003341	Cilium movement	3.04*10−38
		GO:0044782	Cilium organization	6.78*10−37
Triceps muscles	Mus musculus	GO:0061061	Muscle structure development	1.56*10−14
		GO:0055002	Striated muscle cell development	2.41*10−14
		GO:0003009	Skeletal muscle contraction	3.53*10−14
Brain	Rattus norvegicus	GO:0099537	Trans-synaptic signalling	1.79*10−60
		GO:0007268	Chemical synaptic transmission	1.79*10−60
		GO:0098916	Anterograde trans-synaptic signalling	1.79*10−60
Heart	Rattus norvegicus	GO:0061061	Muscle structure development	2.94*10−17
		GO:0003012	Muscle system process	6.30*10−16
		GO:0055001	Muscle cell development	4.00*10−15
Kidney	Rattus norvegicus	GO:0006396	RNA processing	6.19*10−13
		GO:0045944	positive regulation of transcription by RNA polymerase II	7.29*10−06
		GO:0006260	DNA replication	1.74*10−05
Liver	Rattus norvegicus	GO:0008202	Steroid metabolic process	2.74*10−10
		GO:0016054	Organic acid catabolic process	1.61*10−09
		GO:0032787	Monocarboxylic acid metabolic process	1.64*10−09
Lung	Rattus norvegicus	GO:0031589	Cell-substrate adhesion	7.62*10−08
		GO:0009617	Response to bacterium	7.62*10−08
		GO:0030036	Actin cytoskeleton organization	1.40*10−07
Spinal cord	Rattus norvegicus	GO:0061564	Axon development	4.26*10−18
		GO:0099537	Trans-synaptic signalling	5.93*10−16
		GO:0007268	Chemical synaptic transmission	5.93*10−16
Tendon	Rattus norvegicus	GO:0030199	Collagen fibril organization	1.23*10−13
		GO:0061448	Connective tissue development	2.31*10−09
		GO:0001501	Skeletal system development	3.39*10−09
Testis	Rattus norvegicus	GO:0019953	Sexual reproduction	3.98*10−24
		GO:0051704	Multi-organism process	1.61*10−18
		GO:0007018	Microtubule-based movement	4.00*10−12