Table 1.

Effects of m7G risk levels on tumor immune microenvironment.

Immune cell	Variation trend in high m7G risk	Roles in tumor immunity	Final effect on antitumor immunity
CD8T cells	Decreased	CD8+ T cells exert potent cytotoxic effects to eradicate tumour cells	Unfavorable
Follicular helper T cells	Increased	TFH is a subset of CD4+ T cells specialized to prevent excessive antibody response	Unfavorable
Regulatory T cells	Increased	Tregs are capable of suppressing the functions of CD8+ T cells	Unfavorable
Gamma delta T cells	Decreased	The gamma delta T cells have capacities for killing tumor cells	Unfavorable
M0 macrophages	Increased	The polarization of macrophage M1/M2 results in different immune responses	Uncertain
M1 macrophages	Decreased	M1 macrophages can phagocytose tumor cells through their proinflammatory abilities	Unfavorable
M2 macrophages	Decreased	M2 macrophages can promote tumor growth and invasion though their anti-inflammatory abilities	Favorable

m7G, N7-methylguanosine; TFH, follicular helper T cells; Tregs, regulatory T cells.