Figure 10. Secretome/proteome analysis of tracheae stimulated with denatonium.

(A) Log₂(fold change) of peptide enrichment in the supernatants (relative to their concentration in the tracheal cells) after denatonium treatment (y axis) and the corresponding rank (x axis; derived from Bayesian linear model, unadjusted, n = 6). Large dots denote peptides with supernatant concentration after denatonium treatment significantly upregulated both absolutely (in comparison with their concentration in the supernatants of vehicle-treated cells) and relative to their cellular concentration (FDR-corrected P value ≤ 0.05, log₂[fold change] ≥ 1 in both tests). Peptides belonging to the biological processes shown in B are drawn in red and labeled by the names of their genes. (B) Gene Ontology Biological Processes significantly enriched (FDR-corrected Fisher exact test P value ≤ 0.05) among the peptides upregulated by denatonium treatment.