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. 2022 Jul 1;132(13):e145099. doi: 10.1172/JCI145099

Figure 1. RBM10 mutations co-occur with EGFR mutations in LA.

Figure 1

(A) Targeted NGS of 591 EGFR-mutant LA tumors using a panel of 324 cancer-related genes (median coverage depth = 500×). Co-occurring alterations that occurred in at least 5% of EGFR mutation–positive cases are shown. (B) RBM10 alterations were compared across each EGFR-mutant subtype. (C) Mutations in the RBM10 protein-coding sequence (splice site mutations: blue; truncating mutations: red; missense mutations: black). RRM, RNA recognition motifs; ZF, zinc finger; G-patch, glycine patch.