Table 3. Relative abundances at the species level before and after synbiotic supplementation in the non-responders and responders.
| Phylum | Family | Species | Relative abundance (%) | Change (%) | ||
|---|---|---|---|---|---|---|
| Baseline | 24 weeks | 24 weeks | ||||
| Actinobacteriota | Bifidobacteriaceae | Bifidobacterium pseudocatenulatum | Non-responders | 1.3 ± 1.9 | 6.5 ± 8.5 | 5.2 ± 7.4 |
| Responders | 2.8 ± 6.8 | 4.2 ± 4.3 | 1.3 ± 5.7 | |||
| Bifidobacterium kashiwanohense | Non-responders | 0.01 ± 0.03 | 0.01 ± 0.05 | 0.00 ± 0.02 | ||
| Responders | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | |||
| Bifidobacterium adolescentis | Non-responders | 2.3 ± 3.5 | 7.1 ± 9.2 | 4.8 ± 7.2 | ||
| Responders | 4.3 ± 6.4 | 7.6 ± 8.1 | 3.4 ± 7.6 | |||
| Coriobacteriaceae | Collinsella aerofaciens | Non-responders | 0.38 ± 0.40 | 0.46 ± 0.48 | 0.09 ± 0.29 | |
| Responders | 0.78 ± 0.93 | 0.97 ± 0.64* | 0.19 ± 0.76 | |||
| Bacteroidota | Bacteroidaceae | Bacteroides vulgatus | Non-responders | 0.11 ± 0.40 | 0.06 ± 020 | −0.05 ± 0.21 |
| Responders | 0.65 ± 1.53 | 0.44 ± 1.24 | −0.23 ± 0.49 | |||
| Bacteroides uniformis | Non-responders | 2.9 ± 2.8 | 1.9 ± 2.0 | −1.0 ± 2.4 | ||
| Responders | 2.5 ± 3.1 | 2.2 ± 3.4 | −0.4 ± 2.0 | |||
| Bacteroides thetaiotaomicron | Non-responders | 0.47 ± 0.52 | 0.49 ± 0.80 | 0.02 ± 0.67 | ||
| Responders | 0.58 ± 0.57 | 0.35 ± 0.48 | −0.22 ± 0.40 | |||
| Bacteroides stercoris | Non-responders | 2.0 ± 4.0 | 1.8 ± 3.6 | −0.3 ± 0.9 | ||
| Responders | 1.9 ± 3.2 | 1.9 ± 3.4 | −0.1 ± 2.6 | |||
| Bacteroides plebeius | Non-responders | 1.6 ± 3.8 | 2.2 ± 4.8 | 0.6 ± 2.6 | ||
| Responders | 3.0 ± 7.7 | 2.3 ± 5.1 | −0.9 ± 4.5 | |||
| Bacteroides massiliensis | Non-responders | 1.00 ± 2.80 | 0.40 ± 1.41 | −0.59 ± 1.47 | ||
| Responders | 0.66 ± 1.36 | 0.67 ± 1.57 | −0.03 ± 0.70 | |||
| Bacteroides eggerthii | Non-responders | 0.67 ± 1.53 | 0.44 ± 1.06 | −0.23 ± 0.61 | ||
| Responders | 0.09 ± 0.38 | 0.02 ± 0.06 | −0.07 ± 0.35 | |||
| Bacteroides dorei | Non-responders | 0.7 ± 1.9 | 0.9 ± 2.7 | 0.2 ± 0.8 | ||
| Responders | 1.9 ± 4.4 | 1.5 ± 3.3 | −0.4 ± 1.8 | |||
| Bacteroides coprophilus | Non-responders | 0.18 ± 0.58 | 0.09 ± 3.2 | −0.09 ± 0.36 | ||
| Responders | 0.82 ± 2.80 | 0.37 ± 1.59 | −0.49 ± 2.54 | |||
| Bacteroides coprocola | Non-responders | 0.58 ± 2.32 | 0.69 ± 3.01 | 0.11 ± 0.72 | ||
| Responders | 0.14 ± 0.51 | 0.03 ± 0.08 | −0.12 ± 0.49 | |||
| Bacteroides cellulosilyticus | Non-responders | 0.15 ± 0.32 | 0.08 ± 0.21 | −0.08 ± 0.28 | ||
| Responders | 0.08 ± 0.19 | 0.13 ± 0.41 | 0.06 ± 0.24 | |||
| Bacteroides caccae | Non-responders | 0.68 ± 0.81 | 0.78 ± 1.12 | 0.10 ± 0.59 | ||
| Responders | 0.24 ± 0.38* | 0.25 ± 0.44* | 0.01 ± 0.43 | |||
| Marinifilaceae | Odoribacter splanchnicus | Non-responders | 0.16 ± 0.14 | 0.13 ± 0.16 | −0.03 ± 0.12 | |
| Responders | 0.13 ± 0.16 | 0.11 ± 0.13 | −0.02 ± 0.17 | |||
| Prevotellaceae | Prevotella stercorea | Non-responders | 0.75 ± 2.30 | 0.20 ± 0.50 | −0.55 ± 1.94 | |
| Responders | 0.35 ± 1.34 | 0.35 ± 1.01 | 0.02 ± 1.10 | |||
| Prevotella copri | Non-responders | 0.6 ± 2.3 | 0.4 ± 1.3 | −0.2 ± 1.1 | ||
| Responders | 1.1 ± 2.9 | 1.0 ± 1.9 | 0.2 ± 2.1 | |||
| Rikenellaceae | Alistipes onderdonkii | Non-responders | 0.25 ± 0.52 | 0.12 ± 0.28 | −0.12 ± 0.45 | |
| Responders | 0.11 ± 0.26 | 0.15 ± 0.27 | 0.05 ± 0.21 | |||
| Tannerellaceae | Parabacteroides merdae | Non-responders | 1.41 ± 1.60 | 1.29 ± 1.22 | −0.11 ± 1.45 | |
| Responders | 0.55 ± 0.68* | 0.50 ± 0.61* | 0.03 ± 0.52 | |||
| Firmicutes | Acidaminococcaceae | Phascolarctobacterium faecium | Non-responders | 0.30 ± 0.48 | 0.18 ± 0.38 | −0.12 ± 0.38 |
| Responders | 0.29 ± 0.54 | 0.34 ± 0.67 | 0.03 ± 0.41 | |||
| Erysipelotrichaceae | Chlamydia trachomatis | Non-responders | 0.16 ± 0.72 | 0.22 ± 1.01 | 0.06 ± 0.29 | |
| Responders | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | |||
| Lachnospiraceae | Eubacterium hallii | Non-responders | 0.8 ± 1.2 | 0.5 ± 0.7 | −0.3 ± 0.7 | |
| Responders | 0.6 ± 1.0 | 0.4 ± 0.6 | −0.2 ± 0.6 | |||
| Eubacterium rectale | Non-responders | 3.4 ± 4.4 | 2.0 ± 3.3 | −1.4 ± 3.3 | ||
| Responders | 2.1 ± 3.8 | 2.5 ± 4.3 | 0.3 ± 1.6* | |||
| Anaerostipes hadrus | Non-responders | 1.7 ± 2.1 | 1.0 ± 1.3 | −0.7 ± 2.1 | ||
| Responders | 1.5 ± 2.0 | 1.9 ± 2.7 | 0.3 ± 1.3 | |||
| Dorea formicigenerans | Non-responders | 0.19 ± 0.21 | 0.20 ± 0.23 | 0.01 ± 0.23 | ||
| Responders | 0.13 ± 0.17 | 0.12 ± 0.11 | −0.01 ± 0.14 | |||
| Roseburia inulinivorans | Non-responders | 0.51 ± 0.84 | 0.21 ± 0.39 | −0.30 ± 0.57 | ||
| Responders | 0.19 ± 0.34 | 0.14 ± 0.23 | −0.05 ± 0.22 | |||
| Lactobacillaceae | Lactobacillus salivarius | Non-responders | 0.04 ± 0.15 | 0.08 ± 0.24 | 0.03 ± 0.11 | |
| (now Ligilactobacillus salivarius) | Responders | 0.30 ± 0.85 | 0.20 ± 0.80 | −0.12 ± 0.43 | ||
| Lactobacillus mucosae | Non-responders | 0.04 ± 0.18 | 0.13 ± 0.40 | 0.09 ± 0.25 | ||
| (now Limosilactobacillus mucosae) | Responders | 0.36 ± 0.76 | 0.45 ± 1.17 | 0.08 ± 1.00 | ||
| Ruminococcaceae | Faecalibacterium prausnitzii | Non-responders | 0.35 ± 0.59 | 0.25 ± 0.38 | −0.11 ± 0.52 | |
| Responders | 0.35 ± 0.55 | 0.31 ± 0.48 | −0.05 ± 0.53 | |||
| Ruminococcus bicirculans | Non-responders | 0.67 ± 1.27 | 0.94 ± 1.90 | 0.26 ± 1.00 | ||
| Responders | 0.42 ± 1.03 | 0.52 ± 0.92 | 0.08 ± 0.57 | |||
| Selenomonadaceae | Megamonas funiformis | Non-responders | 0.56 ± 1.19 | 0.56 ± 1.57 | 0.00 ± 1.27 | |
| Responders | 0.64 ± 2.20 | 0.18 ± 0.48 | −0.49 ± 1.96 | |||
| Veillonellaceae | Megasphaera elsdenii | Non-responders | 0.08 ± 0.20 | 0.15 ± 0.33 | 0.07 ± 0.23 | |
| Responders | 0.13 ± 0.44 | 0.18 ± 0.68 | 0.14 ± 0.54 | |||
| Veillonella ratti | Non-responders | 0.48 ± 1.01 | 0.74 ± 2.03 | 0.26 ± 1.51 | ||
| Responders | 0.06 ± 0.27 | 0.06 ± 0.30 | 0.01 ± 0.03 | |||
| Fusobacteriota | Fusobacteriaceae | Fusobacterium mortiferum | Non-responders | 0.93 ± 2.51 | 0.38 ± 1.51 | −0.55 ± 1.42 |
| Responders | 0.19 ± 0.88 | 0.01 ± 0.03 | −0.18 ± 0.90 | |||
| Verrucomicrobiota | Akkermansiaceae | Akkermansia muciniphila | Non-responders | 0.29 ± 0.88 | 0.03 ± 0.08 | −0.26 ± 0.86 |
| Responders | 0.13 ± 0.45 | 0.16 ± 0.52 | 0.03 ± 0.71 | |||
Change is expressed as the difference between the value measured at 24 weeks and the baseline value.
*p<0.05 vs. Non-responders.