Table 2.

Summary of the curative effects of TCM decoctions on POF.

Chinese medicine decoction	Ingredients	Sample size	Interventions	Model used	Outcomes	References
Zuogui pill (ZGP)	Rehmanniae radix praeparata, cornel, yam, semen cuscutae, Chinese wolfberry fruit, radix achyranthis bidentatae, colla carapacis et plastri testudinis, and antler gelatin	N = 114	Control group, model group, low-ZGP group, high-ZGP group, low-dose estradiol valerate, high-dose estradiol valerate, DAPT group, and DAPT + low-ZGP group	SD rats	FSH↓; E2, AMH↑; ovarian volume↑; ratio of total ovary weight to body weight↑.	[52]
Bushen huoxue decoction (BHD)	Panax notoginseng powder, rhizoma cyperi, licorice, spatholobus suberectus stem, psoralea corylifolia, rhizoma curculiginis, semen cuscutae, cornel, angelica, epimedium, salvia miltiorrhiza, ligusticum wallichii, codonopsis pilosula, rehmanniae radix praeparata, and radix paeoniae alba.	N = 73	BHD group and western medicine group (estradiol or estradiol didroxyprogesterone tablets)	Human study	FSH↓; AMH↑; TCM syndrome score↓; mir-23a, ovarian artery RI↓.	[58]
Erxian decoction (EXD)	Rhizoma curculiginis, epimedium, morinda officinalis, anemarrhena, phellodendron amurense, and angelica.	N = 60	Normal group, model group, bujiale group, low-EXD group, medium-EXD group, and high-EXD group	SD rats	FSH, LH↓; E2↑; TNF-α, IFN-γ↓; VEGF, bFGF↑.	[63]
Modified mulberry decoction (MMD)	Fructus mori, lilium brownii, angelica, rehmanniae radix praeparata, radix paeoniae alba, epimedium, cistanche, and licorice.	N = 60	Control group: climen tablets treatment group: MMD	Human study	FSH, LH↓; E2↑; TCM syndrome score↓.	[66]
Modified bazhen decoction (MBD)	Bupleurum, angelica, ligusticum wallichii, radix paeoniae alba, glutinous rehmannia, codonopsis pilosula, atractylodes, poria cocos, licorice, antlers, radix achyranthis bidentatae, and rhizoma cyperi	N = 24	Control group, POF group, MBD group, and FES group	SD rats	XIAP↑; mir-23a, mir-27a↓.	[67]
Danggui buxue decoction (DBD)	Angelica and astragalus mongholicus	N = 50	Control group, model group, DBD group, quercetin group, and kaempferol group	SD rats	FSH, LH↓; E2, AMH↑; cytochrome c, Bax, p53 and IL6↓; ,ESR1, AR, Bcl-2↑.	[69]
Si-Wu-Tang (SWT)	Rehmanniae radix praeparata, angelica, paeonia lactiflora pall, and ligusticum wallichii	N = 36	Control group, model group, low-SWT group, medium-SWT group, high-SWT group, and DHEA group	Six C57BLmice	FSH, LH↓; E2, AMH↑; TCM syndrome score↓.	[70]
Wenjing decoction (WJD)	Evodia rutaecarpa, cassia twig, radix paeoniae alba, angelica, ligusticum wallichii, donkey-hide gelatin, ophiopogon japonicus, ginger, rhizoma pinelliae, moutan bark, ginseng, and licorice	N = 119	Control group: HRT (progynat + progesterone capsules) observation group: HRT (progynat + progesterone capsules), WJD, and acupuncture	Human study	FSH, LH↓; E2, AMH↑; TCM syndrome score↓.	[71]

DAPT: dual antiplatelet therapy; FES: Fufang Ejiao Syrup; DHEA: dehydroepiandrosterone; FSH: follicle-stimulating hormone; LH: luteinizing hormone; E2: estrogen; AMH: anti-Müllerian hormone; RI: resistance index; TNF-α: tumor necrosis factor-alpha; IFN-γ: interferon-gamma; VEGF: vascular endothelial growth factor; bFGF: basic fibroblastic growth factor; XIAP: X-linked inhibitor of apoptosis protein; IL6: interleukin-6; ESR1: estrogen receptor 1; AR: androgen receptor.