Table 3.
Summary of the efficacy of Chinese patent medicines on POF.
| Chinese patent medicine | Ingredients | Sample size | Interventions | Model used | Outcomes | References |
|---|---|---|---|---|---|---|
| Kuntai capsule (KTC) | Rehmanniae radix praeparata, rhizoma coptidis, donkey-hide gelatin, radix paeonia alba, poria cocos, and radix scutellariae. | / | / | / | FSH, LH↓; E2, AMH↑; Kupperman score↓. | [77] |
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| Kunbao pills (KBP) | Fructus ligustri lucidi, raspberry, semen cuscutae, Chinese wolfberry fruit, fleeceflower root, tortoise shell, Chinese wolfberry root bark, adenophora tetraphylla, ophiopogon japonicus, wild jujube kernel, glutinous rehmannia, radix paeoniae alba, radix paeoniae rubra, angelica, spatholobus suberectus stem, nacre mother of pearl, dendrobium nobile, chrysanthemum, eclipta, folium mori, radix cynanchi atrati, anemarrhena, and radix scutellariae. | N = 60 | Blank group, model group, low-KBP group, medium-KBP group, high-KBP group, and estrogen combination group | SD rats | FSH, LH↓; E2↑; TGF-β1↓; SCF↓. | [81] |
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| Zishen yutai pill (ZYP) | Semen cuscutae, fructus amomi, rehmanniae radix praeparata, ginseng, parasitic loranthus, donkey-hide gelatin, fleeceflower root, folium artemisiae argyi, morinda officinalis, bighead atractylodes rhizome, codonopsis pilosula, cornu cervi degelatinatum, Chinese wolfberry fruit, teasel root, eucommia ulmoides | N = 80 | The control group (estradiol valerate tablets), the observation group (estradiol valerate tablets combined with ZYP) | Human study | FSH, LH↓; E2↑; Kupperman score↓. | [82] |
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| Fuke yangrong capsule (FYC) | Angelica, bighead atractylodes rhizome, rehmanniae radix praeparata, ligusticum wallichii, radix paeoniae alba, rhizome cyperi, motherwort, astragalus mongholicus, eucommia ulmoides, folium artemisiae argyi, ophiopogon japonicus, donkey-hide gelatin, licorice, dried tangerine peel, poria cocos, fructus amomi | N = 80 | The control group (sequential artificial cycle of estrogen and progesterone) and the observation group (sequential artificial cycle of estrogen and progesterone combined with FYC) | Human study | FSH, LH↓; E2↑; TCM syndrome score↓. | [85] |
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| Qilin pill (QLP) | Prepared fleeceflower root, eclipta, epimedium, semen cuscutae, cynomorium songaricum, codonopsis pilosula, radix curcumae, raspberry, Chinese wolfberry fruit, yam, red-rooted salvia root, astragalus mongholicus, radix paeoniae alba, pericarpium citri reticulatae viride, and fructus mori | N = 72 | Climen tablet group and climen tablets combined with QLP group | Human study | FSH, LH↓; E2↑. | [87] |
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| Bushen Tiaojing cream formula (BTCF) | Rehmanniae radix praeparata, yam, cornel, chinese wolfberry fruit, semen cuscutae, angelica, radix cyathulae, donkey-hide gelatin, motherwort, poria cocos, and moutan bark | N = 110 | The control group (HRT) and the observation group (HRT combined with BTCF) | Human study | FSH, LH↓; E2↑; GDF-9, BMP-15↑. | [90] |
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| Yunkang oral solution (YKos) | Yam, teasel root, astragalus mongholicus, angelica, rhizoma cibotii, semen cuscutae, parasitic loranthus, eucommia ulmoides, psoralea corylifolia, codonopsis pilosula, poria cocos, bighead atractylodes rhizome, donkey-hide gelatin, glutinous rehmannia, cornel, Chinese wolfberry fruit, smoked plum, radix paeoniae alba, fructus amomi, alpinia oxyphylla, radix boehmeriae, radix scutellariae, and folium artemisiae argyi | N = 108 | Control group, CTX model group, positive control group and high-YKos, medium-YKos and low-YKos groups | SD rats | FSH↓; E2↑; ovarian coefficient, uterine coefficient↑; GnRHR, FSHR↑. | [92] |
CTX: cyclophosphamide; FSH: follicle-stimulating hormone; LH: luteinizing hormone; E2: estrogen; AMH: anti-Müllerian hormone; TGF-β1: transforming growth factor beta1; SCF: stem cell factor; GDF-9: growth differentiation factor 9; BMP15: bone morphogenetic protein 15; GnRHR: gonadotropin-releasing hormone receptor; FSHR: follicle-stimulating hormone receptor.