Table 1.
PXN was a prognostic factor independent of recognized prognostic factors.
| Parameter | Univariate cox analysis | Multivariate cox analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| TCGA.OS | ||||||
| PXN | 1.069 | 1.031~1.107 | <0.001 | 1.056 | 1.019~1.093 | 0.003 |
| Age | 1.026 | 1.012~1.041 | <0.001 | 1.023 | 1.008~1.037 | 0.002 |
| Gender | 1.001 | 0.693~1.446 | 0.995 | 1.011 | 0.699~1.463 | 0.954 |
| CGGA.OS | ||||||
| PXN | 1.925 | 1.682~2.203 | <0.001 | 1.279 | 1.122~1.457 | <0.001 |
| Age | 1.025 | 1.016~1.033 | <0.001 | 1.009 | 1.001~1.017 | 0.031 |
| Gender | 1.058 | 0.869~1.288 | 0.575 | 1.006 | 0.824~1.230 | 0.950 |
| Grade | 2.822 | 2.448~3.253 | <0.001 | 2.243 | 1.898~2.651 | <0.001 |
| Radiotherapy | 0.907 | 0.714~1.153 | 0.427 | 0.787 | 0.614~1.011 | 0.061 |
| Chemotherapy | 1.215 | 0.973~1.518 | 0.086 | 0.678 | 0.535~0.859 | 0.001 |
| IDH mutation | 0.325 | 0.265~0.397 | <0.001 | 0.799 | 0.624~1.021 | 0.073 |
| 1p19q Codel | 0.224 | 0.160~0.312 | <0.001 | 0.401 | 0.280~0.575 | <0.001 |
| MGMT promoter methylation | 0.846 | 0.697~1.027 | 0.092 | 0.953 | 0.778~1.167 | 0.643 |
| GSE83300.OS | ||||||
| PXN | 1.705 | 1.066~2.727 | 0.026 | 2.137 | 1.225~3.727 | 0.007 |
| Gender | 1.415 | 0.746~2.683 | 0.288 | 1.745 | 0.846~3.598 | 0.132 |
| Age | 1.049 | 1.017~1.081 | 0.002 | 1.049 | 1.015~1.083 | 0.004 |
| TCGA.PFS | ||||||
| PXN | 1.067 | 1.028~1.107 | 0.001 | 1.059 | 1.021~1.099 | 0.002 |
| Age | 1.015 | 1.002~1.028 | 0.024 | 1.013 | 0.999~1.026 | 0.06 |
| Gender | 1.153 | 0.799~1.663 | 0.447 | 1.179 | 0.817~1.702 | 0.378 |