Table 1.
The oxidative stress-related DEGs in LAC tissues.
| Gene | logFC | Gene | logFC | Gene | logFC | Gene | logFC |
|---|---|---|---|---|---|---|---|
| GPX2 | 6.013780623 | SUMO4 | 2.257715062 | PCNA | 1.251080564 | NFIX | -1.302326118 |
| S100A7 | 5.41728031 | FBXO32 | 2.253504422 | PPIF | 1.228327064 | JUND | -1.316092598 |
| MMP11 | 5.370660455 | ERO1A | 2.169220374 | P4HB | 1.224045072 | SNCA | -1.343581323 |
| GJB2 | 4.664130361 | MMP9 | 2.153880308 | CBX4 | 1.194091529 | TLR4 | -1.375114638 |
| PTPRN | 4.431031909 | CDH2 | 2.13556165 | GCLM | 1.175006466 | AQP1 | -1.395667559 |
| UBE2C | 4.33254131 | MT1H | 2.048791978 | UTP25 | 1.172874466 | HMOX1 | -1.474996851 |
| WNT16 | 4.221055426 | MARCKSL1 | 2.0461911 | ERBB2 | 1.170033481 | SESN1 | -1.488992986 |
| XDH | 4.189103258 | SLC4A11 | 2.023752334 | SPINT2 | 1.147192812 | ERBB4 | -1.508245365 |
| MMP3 | 4.042213517 | PDK1 | 1.897233653 | CALU | 1.146319227 | SELENOP | -1.513089809 |
| MYBL2 | 3.97196672 | ITGB4 | 1.769385266 | RGS14 | 1.130235535 | FOS | -1.547672977 |
| CDC20 | 3.923133178 | TXNRD1 | 1.713452233 | NME2 | 1.120700065 | KRT1 | -1.611799687 |
| PYCR1 | 3.849785485 | FANCD2 | 1.694266871 | GSR | 1.118622392 | BMP2 | -1.62052111 |
| CDC25C | 3.822823814 | WNT1 | 1.652280572 | NUDT1 | 1.110791055 | KLF2 | -1.630982183 |
| MELK | 3.79228364 | ABCB11 | 1.648035243 | OAT | 1.108313278 | RCAN1 | -1.645841006 |
| CDKN2A | 3.660292428 | IGFBP2 | 1.643496508 | TCF3 | 1.106493729 | FBLN5 | -1.650383453 |
| PLK1 | 3.355128242 | E2F1 | 1.629703342 | IER3 | 1.104634685 | ALOX5 | -1.670847714 |
| SLC7A11 | 3.206827355 | GDF15 | 1.594567934 | CDK4 | 1.1019358 | MSRB3 | -1.695874161 |
| NOX5 | 3.181844416 | FUT8 | 1.582037385 | PARP1 | 1.097260888 | EGR1 | -1.730851757 |
| NQO1 | 3.122327878 | CYP2E1 | 1.575457932 | MGST1 | 1.083753103 | CHRNA4 | -1.759665302 |
| HGFAC | 3.084341171 | NOX1 | 1.572211162 | NR2F6 | 1.077443474 | CAT | -1.761079975 |
| COL1A1 | 3.04475487 | E2F3 | 1.541174573 | DHFR | 1.064060918 | CYP1A1 | -1.771485237 |
| CCNA2 | 3.037368198 | UCN | 1.536180525 | NOL3 | 1.017279978 | HYAL1 | -1.793702837 |
| CDH3 | 2.906398001 | PRDX4 | 1.524830048 | HBB | -4.072278882 | CRYAB | -1.799207942 |
| GPR37 | 2.892829344 | SRXN1 | 1.523512148 | HBA2 | -3.971614753 | LRRK2 | -1.837429368 |
| SLC7A5 | 2.832579597 | TPO | 1.497068338 | ETS1 | -1.009611374 | EDN1 | -1.837496875 |
| TRPA1 | 2.725732428 | NET1 | 1.492518868 | JUNB | -1.029141797 | CA3 | -1.923666594 |
| EZH2 | 2.71140365 | NOX4 | 1.469389165 | ETV5 | -1.03192463 | SLC1A1 | -2.043700892 |
| SGK2 | 2.696077295 | CBX8 | 1.467297358 | ITGAL | -1.045741495 | NR4A3 | -2.088467157 |
| CDK1 | 2.607317686 | G6PD | 1.459631279 | VIM | -1.048813585 | KCNA5 | -2.103363458 |
| CBX2 | 2.603102932 | MET | 1.424801169 | CYGB | -1.072716336 | GPX3 | -2.12554072 |
| LPO | 2.537856476 | FMO1 | 1.418278305 | MYLK | -1.073347764 | DUOX1 | -2.428487405 |
| E2F2 | 2.515712683 | TRPM2 | 1.383090886 | SIRPA | -1.104069804 | HBEGF | -2.431447934 |
| CDC25A | 2.506554418 | PRKAA2 | 1.373646285 | SELENBP1 | -1.12795438 | EPAS1 | -2.587591866 |
| HMGA1 | 2.412891462 | GPR37L1 | 1.36067259 | CDKN2B | -1.146620037 | IL6 | -2.664089275 |
| FOXO6 | 2.408776331 | IPCEF1 | 1.347748923 | CYBB | -1.155101406 | CD36 | -2.768036549 |
| CHEK1 | 2.394961963 | TAT | 1.339357309 | HYAL2 | -1.155726104 | AGRP | -2.793810482 |
| GCLC | 2.381107058 | GPX8 | 1.337343767 | NCF1 | -1.157427085 | RETN | -2.813480794 |
| MCM4 | 2.359143052 | MAP2K6 | 1.332194326 | UTRN | -1.180127364 | MGAT3 | -2.885893674 |
| ECT2 | 2.328988223 | MMP14 | 1.302518357 | BTK | -1.217464546 | SCGB1A1 | -3.072434982 |
| EFNA4 | 2.310996951 | TRAP1 | 1.281380934 | PPARGC1B | -1.249251755 | ANGPTL7 | -3.157773456 |
| HYOU1 | 1.280070739 | BNIP3 | 1.270862371 | HBA1 | -4.201724914 |
Note: LAC: lung adenocarcinoma; DEGs: differentially expressed genes.